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Titolo:
Enrofloxacin-associated retinal degeneration in cats
Autore:
Gelatt, KN; van der Woerdt, A; Ketring, KL; Andrew, SE; Brooks, DE; Biros, DJ; Denis, HM; Cutler, TJ;
Indirizzi:
Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Clin Sci, Gainesville, FL 32610 USA Anim Med Ctr, New York, NY USA Anim Med Ctr New York NY USAAnim Med Ctr, New York, NY USA All Anim Eye Clin, Cincinnati, OH USA All Anim Eye Clin Cincinnati OH USA ll Anim Eye Clin, Cincinnati, OH USA
Titolo Testata:
VETERINARY OPHTHALMOLOGY
fascicolo: 2, volume: 4, anno: 2001,
pagine: 99 - 106
SICI:
1463-5216(200106)4:2<99:ERDIC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED OCULAR HYPERTENSION; DOGS; OFLOXACIN; CIPROFLOXACIN; GLAUCOMA; RABBITS; BEAGLES;
Keywords:
enrofloxacin; feline; retinal degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Gelatt, KN Univ Florida, Coll Vet Med, Dept Small Anim Clin Sci, Box 100126, Gainesville, FL 32610 USA Univ Florida Box 100126 Gainesville FL USA 32610 , FL 32610 USA
Citazione:
K.N. Gelatt et al., "Enrofloxacin-associated retinal degeneration in cats", VET OPHTHAL, 4(2), 2001, pp. 99-106

Abstract

Objective The objective of this study was to evaluate the possible relationship between the administration of parenteral enrofloxacin and the onset of acute retinal degeneration The animals studied included 17 cats that received systemic enrofloxacin and in cats. developed retinal degeneration soonthereafter. Procedures In this retrospective clinical study, cats that received parenteral enrofloxacin and developed acute blindness were identified. Parametersrecorded included breed, age, sex, enrofloxacin dosage (daily dose and number of days administered), medical condition for which the antibiotic had been prescribed, ophthalmic signs, examination results, and the visual outcome. Fundus photographs were obtained in seven cats, and electroretinographywas performed in five cats. Histopathology was performed on two eyes from one cat (case 1) that received enrofloxacin 5 months previously and developed retinal degeneration. Results All cats were the domestic shorthair breed; seven were females (one neutered) and ten were males (seven castrated). Ages ranged from 3 to 16 years old (mean +/- SD; 8.8 +/- 4.6 years). The medical disorders for whichenrofloxacin was administered ranged from lymphoma and pancreatitis to otitis and dermatitis, and eight cats had urinary diseases. The daily and total dosage of enrofloxacin and number of days of administration were also highly variable. Presenting clinical signs were most often mydriasis and acuteblindness. All cats had diffuse retinal degeneration as evidenced by increased tapetal reflectivity and retinal vascular attenuation. Absence of recordable electroretinographic responses suggested diffuse and extensive outerretinal disease. Vision returned in a few cats, but the retinal degeneration persisted or even progressed. Histopathology of two eyes revealed primarily outer retinal degeneration, with diffuse loss of the outer nuclear and photoreceptor layers, and hypertrophy and proliferation of the retinal pigment epithelium. Conclusion Parenteral enrofloxacin is potentially retinotoxic in some cats, and may result in acute and diffuse retinal degeneration. Blindness oftenresults, but some cats may regain vision. Practitioners should adhere closely to the manufacturer's current enrofloxacin dosage recommendation (5 mg/kg q 24 h), and continue clinical observations for this drug toxicity in cats.

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Documento generato il 25/01/20 alle ore 03:23:57