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Titolo:
Immunogenicity of a DNA vaccine against herpes B virus in mice and rhesus macaques
Autore:
Loomis-Huff, JE; Eberle, R; Lockridge, KM; Rhodes, G; Barry, PA;
Indirizzi:
Univ Calif Davis, Sch Med, Ctr Comparat Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Ctr Comparat Med, Davis, CA 95616 USA Univ Calif Davis, Sch Med, Dept Med Pathol, Davis, CA 95616 USA Univ CalifDavis Davis CA USA 95616 Dept Med Pathol, Davis, CA 95616 USA Oklahoma State Univ, Coll Vet Med, Dept Vet Pathobiol, Stillwater, OK 74078 USA Oklahoma State Univ Stillwater OK USA 74078 iol, Stillwater, OK 74078 USA
Titolo Testata:
VACCINE
fascicolo: 32, volume: 19, anno: 2001,
pagine: 4865 - 4873
SICI:
0264-410X(20010914)19:32<4865:IOADVA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEIC-ACID IMMUNIZATION; RECURRENT GENITAL HERPES; CYTOTOXIC T-LYMPHOCYTES; IMMUNE-RESPONSES; GLYCOPROTEIN-D; NONHUMAN-PRIMATES; PROTECTIVE IMMUNITY; PLASMODIUM-FALCIPARUM; NEUTRALIZING ANTIBODY; BREEDING COLONIES;
Keywords:
Cercopithecine herpesvirus 1; B virus; DNA vaccination; Macaca mulatta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Barry, PA Univ Calif Davis, Sch Med, Ctr Comparat Med, Davis, CA 95616 USAUniv Calif Davis Davis CA USA 95616 at Med, Davis, CA 95616 USA
Citazione:
J.E. Loomis-Huff et al., "Immunogenicity of a DNA vaccine against herpes B virus in mice and rhesus macaques", VACCINE, 19(32), 2001, pp. 4865-4873

Abstract

Herpes B virus (Cercopithecine herpesvirus 1) is endemic in captive macaque populations and poses a serious threat to humans who work with macaques or their tissues. A vaccine that could prevent or limit B virus infection inmacaques would lessen occupational risk. To that end, a DNA vaccine plasmid expressing the B virus glycoprotein B (gB) was constructed and tested forimmunogenicity in mice and macaques. Intramuscular (IM) or intradermal (ID) immunization in mice elicited antibodies to gB that were relatively stable over time and predominately of the IgG2a isotype. Five juvenile macaques were immunized by either IM + ID (n = 2) or IM (n = 3) routes, with two booster immunizations at 10 and 30 weeks. All five animals developed antibodies to B virus gB, with detectable neutralizing activity in the IM + ID immunized animals. These results demonstrated that DNA immunization can be used to generate an immune response against a B virus glycoprotein in uninfectedmacaques. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:35:59