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Titolo:
Neural mechanisms underlying the pubertal increase in LHRH release in the rhesus monkey
Autore:
Richter, TA; Terasawa, E;
Indirizzi:
Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA Univ Wisconsin Madison WI USA 53715 rimate Res Ctr, Madison, WI 53715 USA Univ Wisconsin, Dept Pediat, Madison, WI 53715 USA Univ Wisconsin MadisonWI USA 53715 n, Dept Pediat, Madison, WI 53715 USA
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 8, volume: 12, anno: 2001,
pagine: 353 - 359
SICI:
1043-2760(200110)12:8<353:NMUTPI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL BASAL HYPOTHALAMUS; GAMMA-AMINOBUTYRIC-ACID; HORMONE-RELEASE; MACACA-MULATTA; GONADOTROPIN-SECRETION; INVIVO RELEASE; NEUROPEPTIDE-Y; FEMALE MICE; LEPTIN; ONSET;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Richter, TA Univ Wisconsin, Wisconsin Reg Primate Res Ctr, 1223 Capitol Court, Madison, WI 53715 USA Univ Wisconsin 1223 Capitol Court Madison WI USA53715 715 USA
Citazione:
T.A. Richter e E. Terasawa, "Neural mechanisms underlying the pubertal increase in LHRH release in the rhesus monkey", TRENDS ENDO, 12(8), 2001, pp. 353-359

Abstract

Puberty is triggered by an increase in pulsatile release of luteinizing hormone-releasing hormone (LHRH) from the hypothalamus. Although the LHRH neurosecretory system is mature well before the onset of puberty, a central inhibitory mechanism restrains LHRH release in juvenile primates. Recent studies suggest that this central inhibition is primarily because of GABAergic neurotransmission. A reduction of GABAergic restraint appears to be essential for the initiation of puberty, but the mechanism that underlies the disinhibition process remains to be elucidated. Future research into the regulation of central inhibition should provide more effective treatments for theprevention of disease associated with abnormal pubertal development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:56:01