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Titolo:
Targeted gene regulation and gene ablation
Autore:
DeMayo, FJ; Tsai, SY;
Indirizzi:
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cellular Biol, Houston, TX 77030 USA
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 8, volume: 12, anno: 2001,
pagine: 348 - 353
SICI:
1043-2760(200110)12:8<348:TGRAGA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SITE-SPECIFIC RECOMBINATION; TETRACYCLINE-DEPENDENT TRANSACTIVATOR; CHIMERIC CRE RECOMBINASE; TRANSGENIC MICE; MAMMALIAN-CELLS; SOMATIC MUTAGENESIS; IN-VIVO; CONDITIONAL EXPRESSION; RESPONSIVE PROMOTER; ECDYSONE RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: DeMayo, FJ Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ol, Houston, TX 77030 USA
Citazione:
F.J. DeMayo e S.Y. Tsai, "Targeted gene regulation and gene ablation", TRENDS ENDO, 12(8), 2001, pp. 348-353

Abstract

Investigations of the mechanisms involved in appropriate, developmentally regulated tissue-specific gene transcription have laid the foundations for transgenic and gene-therapy technologies directing specific induction or ablation of genes of interest in a tissue-restricted manner. This technology has further evolved to allow for temporal control of gene expression and ablation. Genes can now be switched on and off or be ablated by administeringexogenous compounds. These technologies are based on the development of ligand-inducible transcription factors or recombinases that regulate gene expression or ablation by the administration of specific ligands and should lead to animal models that are better suited for investigating the molecular basis of human disease. This review describes the evolution, components andapplications of systems that are currently being employed in transgenic and mutant-mouse technology for the conditional regulation of gene expressionand ablation.

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Documento generato il 10/04/20 alle ore 01:51:18