Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The role of SGK1 in hormone-regulated sodium transport
Autore:
Pearce, D;
Indirizzi:
Univ Calif San Francisco, Div Nephrol, Dept Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA
Titolo Testata:
TRENDS IN ENDOCRINOLOGY AND METABOLISM
fascicolo: 8, volume: 12, anno: 2001,
pagine: 341 - 347
SICI:
1043-2760(200110)12:8<341:TROSIH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
THREONINE PROTEIN-KINASE; EPITHELIAL NA+ CHANNEL; CULTURED KIDNEY-CELLS; MINERALOCORTICOID RECEPTORS; COLLECTING DUCT; PHOSPHOINOSITIDE 3-KINASE; GLUCOCORTICOID RECEPTORS; ALDOSTERONE ACTION; PROMOTER ACTIVITY; INDUCIBLE KINASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Pearce, D Univ Calif San Francisco, Div Nephrol, Dept Med, Box 0532, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0532 San Francisco CA USA 94143 USA
Citazione:
D. Pearce, "The role of SGK1 in hormone-regulated sodium transport", TRENDS ENDO, 12(8), 2001, pp. 341-347

Abstract

Ion transport in epithelia is regulated by a variety of hormonal and nonhormonal factors, including mineralocorticoids, insulin, shear stress and osmotic pressure. In mammals, the mineralocorticoid aldosterone is the principal regulator of sodium homeostasis and hence is central to the control of extracellular fluid volume and blood pressure. Aldosterone acts through a member of the nuclear receptor superfamily, the mineralocorticoid receptor (MR),to control the transcriptional activity of specific target genes. Recently, a serine/threonine kinase, SGK1 (serum and glucocorticoid-regulated kinase isoform 1) was identified as a candidate mediator of aldosterone actionin the colon and distal nephron. The aldosterone-activated MR increases SGK1 gene transcription and SGK1, in turn, strongly stimulates the activity of the epithelial sodium channel (ENaC). Interestingly, other factors appearto regulate SGK1 gene expression and kinase activity, Insulin, for example, stimulates SGK1 activity (but not gene transcription) through its effectson phosphatidylinositol-3-kinase and osmotic shock appears to stimulate both SGK1 activity and gene transcription. Hence, SGK1 might integrate the effects of multiple hormonal and nonhormonal regulators of Na+ transport in tight epithelia and thereby play a key role in volume homeostasis. It is interesting to speculate that SGK1 might be implicated in medical conditions, such as the insulin resistance syndrome, hypertension and congestive heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:10:07