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Titolo:
Long-acting bronchodilators in premenstrual exacerbation of asthma
Autore:
Magadle, R; Berar-Yanay, N; Weiner, P;
Indirizzi:
Hillel Yaffe Med Ctr, Dept Med A, IL-38100 Hadera, Israel Hillel Yaffe MedCtr Hadera Israel IL-38100 d A, IL-38100 Hadera, Israel
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 9, volume: 95, anno: 2001,
pagine: 740 - 743
SICI:
0954-6111(200109)95:9<740:LBIPEO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENSTRUAL-CYCLE; SYMPTOMS; WOMEN; ESTROGEN; THERAPY;
Keywords:
asthma; deterioration; PME; LABD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Weiner, P Hillel Yaffe Med Ctr, Dept Med A, IL-38100 Hadera, Israel HillelYaffe Med Ctr Hadera Israel IL-38100 100 Hadera, Israel
Citazione:
R. Magadle et al., "Long-acting bronchodilators in premenstrual exacerbation of asthma", RESP MED, 95(9), 2001, pp. 740-743

Abstract

Premenstrual exacerbation (PME) of asthma occurs during the 5-10 days leading up to the menses and can be demonstrated in about 40% of asthmatic females. Peak expiratory flow rate (PEFR) and beta (2)-agonist consumption wererecorded during three menstrual cycles in 67 females with mild-severe asthma. All were treated with inhaled glucocorticosteroids (IGC) and beta (2)-agonists, as required. Following, the patients with a premenstrual reductionin PEFR > 20%. received either salmeterol, 50 mug x 2 day(-1) or placebo, in the 10 days leading up to the menses, in a randomized, double-blind, cross-over design. Thirteen patients (19.4%) showed PME (mean +/- SEM decreasein PEFR 27 +/- 2.2%) in association with a significant increase in the mean daily beta (2)-agonist consumption. Following administration of salmeterol, there was a complete ablation of the PME in seven patients, a partial ablation in two patients and no effect in the remaining four patients. Only one patient showed a partial ablation of the PME following placebo. There was also a significant decrease in the beta (2)-agonists consumption in the responders. About 20% of the women with asthma, under chronic IGC treatment,had PME of asthma. In 54% of them, it could be prevented by the use of long-acting bronchodilators (LABD) during the 10 days leading up to the menses, and partially prevented in another 15%. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:32:25