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Titolo:
Thymic lesions in patients with myasthenia gravis: Characterization with thallium 201 scintigraphy
Autore:
Higuchi, T; Taki, J; Kinuya, S; Yamada, M; Kawasuji, M; Matsui, O; Nonomura, A; Bunko, H; Tonami, N;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Nucl Med, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Sch Med, Dept Neurol, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Sch Med, Dept Surg 1, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan Kanazawa Univ, Sch Med, Dept Radiol, Kanazawa, Ishikawa, Japan Kanazawa Univ Kanazawa Ishikawa Japan Radiol, Kanazawa, Ishikawa, Japan Kanazawa Univ, Sch Med, Dept Pathol, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan
Titolo Testata:
RADIOLOGY
fascicolo: 1, volume: 221, anno: 2001,
pagine: 201 - 206
SICI:
0033-8419(200110)221:1<201:TLIPWM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPUTED-TOMOGRAPHY; THYMECTOMY; TUMORS; TL-201; THYMOMA; BENIGN; SPECT; BONE; PET; CT;
Keywords:
mediastinum, radionuclide studies; myasthenia gravis; thallium, radioactive; thymus, CT; thymus, neoplasms; thymus, radionuclide studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Higuchi, T Kanazawa Univ, Sch Med, Dept Nucl Med, Takaramachi 13-1, Kanazawa, Ishikawa 920, Japan Kanazawa Univ Takaramachi 13-1 Kanazawa Ishikawa Japan 920 apan
Citazione:
T. Higuchi et al., "Thymic lesions in patients with myasthenia gravis: Characterization with thallium 201 scintigraphy", RADIOLOGY, 221(1), 2001, pp. 201-206

Abstract

PURPOSE: To assess thallium 201 (Tl-201) single photon emission computed tomography (SPECT) for evaluation of thymic lesions associated with myasthenia gravis (MG), including lymphoid follicular hyperplasia (LFH) and thymoma. MATERIALS AND METHODS: Tl-201 SPECT and computed tomography (CT) were performed preoperatively in 46 patients with MG who had undergone thymectomy. SPECT was conducted 15 (early image) and 180 (delayed image) minutes after Tl-201 injection. Results were visually assessed, and Tl-201 uptake ratios (thymic lesion count density/lung count density) were measured for quantitative analysis. Uptake was analyzed among the normal thymus, LFH, and thymomapatient groups. RESULTS: Histopathologic results indicated a normal thymus, LFH, and thymoma in 19, 16, and I I patients, respectively. Mean uptake ratios in the normal thymus, LFH, and thymoma were 0.96 (95% CI: 0.90, 1.03), 1.14 (95% CI: 1.04, 1.25), and 1.87 (95% CI: 1.56, 2.25), respectively, on early images and 1.09 (95% CI: 1.00, 1.18), 1.65 (95% CI: 1.48, 1.85), and 2.03 (95% Cl: 1.65, 2.50), respectively, on delayed images. Thymoma showed more intense Tl-201 accumulation than did the normal thymus (P < .001) and LFH (P <.001) on early images. Both thymoma (P <.001) and LFH (P <.001) displayed more intense uptake than did the normal thymus on delayed images. CONCLUSION : Tl-201 SPECT can enable differentiation between normal thymus, LFH, and thymoma in patients with MG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:37:19