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Titolo:
Radiation target analysis of enzymes with stable free radicals
Autore:
Miller, JH; Bolger, G; Kempner, E;
Indirizzi:
NIAMSD, Phys Biol Lab, NIH, Bethesda, MD 20892 USA NIAMSD Bethesda MD USA20892 , Phys Biol Lab, NIH, Bethesda, MD 20892 USA Boehringer Ingelheim Canada Ltd, Dept Biol Sci, BioMega Res Div, Laval, PQH7S 2G5, Canada Boehringer Ingelheim Canada Ltd Laval PQ Canada H7S 2G5 PQH7S 2G5, Canada
Titolo Testata:
RADIATION PHYSICS AND CHEMISTRY
fascicolo: 1, volume: 62, anno: 2001,
pagine: 33 - 38
SICI:
0969-806X(200107)62:1<33:RTAOEW>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMPLEX VIRUS TYPE-1; COLI RIBONUCLEOTIDE REDUCTASE; ESCHERICHIA-COLI; GALACTOSE-OXIDASE; PROTEIN R2; INACTIVATION; PHENYLALANINE; SEQUENCE; SUBUNIT; SITE;
Keywords:
target size; protein function and protein structure; ribonucleotide reductase; galactose oxidase; radiation inactivation; energy transfer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kempner, E NIAMSD, Phys Biol Lab, NIH, Bldg 6,Room 140, Bethesda, MD 20892USA NIAMSD Bldg 6,Room 140 Bethesda MD USA 20892 esda, MD 20892 USA
Citazione:
J.H. Miller et al., "Radiation target analysis of enzymes with stable free radicals", RADIAT PH C, 62(1), 2001, pp. 33-38

Abstract

Irradiation of ribonucleotide reductase yielded a functional target size of the entire tetramer. The free radical-containing R2 subunit target size for activity was much larger than the physical structure while that for lossof structure was similar to the monomer. This indicates that indirect effects of ionizing radiation removed the free radical in the isolated R2 without substantial structural damage. Preliminary results of galactose oxidase indicate a target mass equal to the monomer size. No indirect effects were observed on the free radical which is not accessible to the solvent. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 14:51:55