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Titolo:
Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde
Autore:
McGrath, LT; McGleenon, BM; Brennan, S; McColl, D; McIlroy, S; Passmore, AP;
Indirizzi:
Queens Univ Belfast, Dept Geriatr Med, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT9 7BL m, North Ireland
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 9, volume: 94, anno: 2001,
pagine: 485 - 490
SICI:
1460-2725(200109)94:9<485:IOSIAD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIOXIDANT ENZYME-ACTIVITY; AMYLOID BETA-PEPTIDE; LIPID-PEROXIDATION; VASCULAR DEMENTIA; BRAIN; BLOOD; PROTEIN; PRODUCT; DAMAGE; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Passmore, AP Queens Univ Belfast, Dept Geriatr Med, Whitla Med Bldg,97 Lisburn Rd, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Whitla Med Bldg,97 Lisburn Rd Belfast Antrim North Ireland BT9 7BL
Citazione:
L.T. McGrath et al., "Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde", QJM-MON J A, 94(9), 2001, pp. 485-490

Abstract

Oxidative stress is thought to play a major role in the pathogenesis of Alzheimer's disease (AD). Although there is strong post-mortem and experimental evidence of oxidative damage occurring in AD brains, the use of markers in the peripheral circulation to show oxidative stress is less convincing. We examined plasma from AD patients for markers of increased oxidative stress. We report elevated levels of 4-hydroxy-nonenal (4-HNE) in AD patients compared to controls (median 20.6, IQR 6.0-25.2 vs. 7.8, 3.3-14.5 mu mol/l, respectively; p = 0.001) but not malondialdehyde (MDA), and lower levels ofascorbate in AD plasma when compared to age-matched controls (9.9, 6.0-33.7 vs. 24.2, 13.9-48.6 mu mol/l; p < 0.05). Levels of 4-HNE in AD patients were inversely related to ascorbate (r = -0.337; p = 0.07) and Folstein Mini-Mental State Examination (MMSE) (r = -0.474; P=0.015). The concentration of protein sulphydryls, free-radical scavengers, was directly related to theMMSE result (r = 0.427; p = 0.03). Increased production of 4-HNE indicatesincreased oxidative stress (lipid peroxidation), which is not evident using the more common marker MDA. This elevation of 4-HNE was related to the degree of cognitive impairment (MMSE).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:15:32