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Titolo:
The anti-inflammatory effects of circulating fatty acids in obstructive jaundice: similarities with pregnancy-induced immunosuppression
Autore:
Crocker, IP; Lawson, N; Baker, PN; Fletcher, J;
Indirizzi:
Univ Nottingham, Nottingham City Hosp NHS Trust, Med Res Ctr, Nottingham NG5 1PB, England Univ Nottingham Nottingham England NG5 1PB , Nottingham NG5 1PB, England Univ Nottingham, Nottingham City Hosp NHS Trust, Dept Clin Chem, Nottingham NG5 1PB, England Univ Nottingham Nottingham England NG5 1PB , Nottingham NG5 1PB, England Univ Nottingham, Nottingham City Hosp NHS Trust, Sch Human Dev, NottinghamNG5 1PB, England Univ Nottingham Nottingham England NG5 1PB v, NottinghamNG5 1PB, England
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 9, volume: 94, anno: 2001,
pagine: 475 - 484
SICI:
1460-2725(200109)94:9<475:TAEOCF>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMORPHONUCLEAR LEUKOCYTE FUNCTION; RHEUMATOID-ARTHRITIS; HUMAN NEUTROPHILS; NADPH OXIDASE; IMMUNITY; LIPIDS; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Crocker, IP Univ Nottingham, Nottingham City Hosp NHS Trust, Div Obstet & Gynaecol, Hucknall Rd, Nottingham NG5 1PB, England Univ Nottingham HucknallRd Nottingham England NG5 1PB ngland
Citazione:
I.P. Crocker et al., "The anti-inflammatory effects of circulating fatty acids in obstructive jaundice: similarities with pregnancy-induced immunosuppression", QJM-MON J A, 94(9), 2001, pp. 475-484

Abstract

Rheumatoid arthritis (RA) is ameliorated during both obstructive jaundice and pregnancy. Previous studies of polymorphonuclear leukocyte (PMN) function during pregnancy have shown reductions in the stimulated release of arachidonic acid (AA) and leukotriene B-4 (LTB4), and lower NADPH oxidase activity. These changes may account for the amelioration of RA. The cause of this reduction in PMN function appears to be a progressive change in circulating fatty acids (FA), with a reduction in polyunsaturated FA, predominantly AA. The NADPH oxidase responsible for the respiratory burst has a direct requirement for polyunsaturated FA, particularly AA. We investigated whether the same changes in PMN function and FA, occur during obstructive jaundice. Patients with biliary obstructions were investigated before and after surgical correction (n=14). Obstructive jaundice caused significant changes in the proportions of serum and cellular FA. There was a striking reduction inpolyunsaturated FA, particularly AA (48% in serum, p<0.001; 42% in PMNs, p<0.001) and an increase in mono-unsaturated oleic acid (24% in serum, p<0.001; 15% in PMNs, p<0.005). Similar changes occurred in mononuclear cell FA.jaundice also caused a significant reduction in PMN function. Respiratory burst activity was reduced by between 32% and 38% in response to physiological and nonphysiological stimuli, and there were similar significant reductions in the release of AA and LTB4. These changes in stimulated PMN function were evident whether or not the cells were first primed with tumour necrosis factor alpha (TNF alpha). Incubation of PMNs from healthy donors in pooled serum from patients with obstructive jaundice caused a reduction of 32%in cellular AA and 38% in NADPH oxidase activity. These findings support the idea that circulating FA can regulate PMN inflammatory responsiveness. The FA-induced attenuation in PMN activity in both jaundice and pregnancy may explain their ameliorating effects upon RA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:14:52