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Titolo:
Analysis of urinary prostacyclin and thromboxane/prostacyclin ratio in patients with rheumatoid arthritis using gas chromatography/selected ion monitoring
Autore:
Hishinuma, T; Nakamura, H; Sawai, T; Mitomo, T; Inoue, H; Matsumoto, F; Mizugaki, M;
Indirizzi:
Tohoku Univ Hosp, Dept Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Hosp Sendai Miyagi Japan 9808574 endai, Miyagi 9808574, Japan Iwate Med Univ, Dept Pathol 1, Morioka, Iwate, Japan Iwate Med Univ Morioka Iwate Japan Dept Pathol 1, Morioka, Iwate, Japan Tohoku Koseinenkin Hosp, Ctr Rheumatol, Sendai, Miyagi, Japan Tohoku Koseinenkin Hosp Sendai Miyagi Japan matol, Sendai, Miyagi, Japan Tohoku Rosai Hosp, Div Orthoped, Sendai, Miyagi, Japan Tohoku Rosai Hosp Sendai Miyagi Japan iv Orthoped, Sendai, Miyagi, Japan Naruko Natl Hosp, Div Orthoped, Sendai, Miyagi, Japan Naruko Natl Hosp Sendai Miyagi Japan Div Orthoped, Sendai, Miyagi, Japan
Titolo Testata:
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
fascicolo: 2, volume: 65, anno: 2001,
pagine: 85 - 90
SICI:
0952-3278(200108)65:2<85:AOUPAT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN E-2; ARACHIDONIC-ACID; SYNOVIAL TISSUES; JOINT FLUID; THROMBOXANE; INTERLEUKIN-1-BETA; MICRODETERMINATION; CYCLOOXYGENASE-2; EXPRESSION; ADJUVANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Mizugaki, M Tohoku Univ Hosp, Dept Pharmaceut Sci, Aoba Ku, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ Hosp 1-1 Seiryo Machi Sendai Miyagi Japan 9808574
Citazione:
T. Hishinuma et al., "Analysis of urinary prostacyclin and thromboxane/prostacyclin ratio in patients with rheumatoid arthritis using gas chromatography/selected ion monitoring", PROS LEUK E, 65(2), 2001, pp. 85-90

Abstract

We investigated production of prostacyclin and the urinary ratio of thromboxane and prostacyclin inpatients with rheumatoid arthritis. The prostacyclin production level was assessed according to the level of urinary 2,3-dinor-6-ketoprostaglandin F-1 alpha measuring by gas chromatography/selected ion monitoring. Inpatients receiving medication, the prostacyclin level was lower and the thromboxane/prostacyclin ratio was greater compare with that of healthy volunteers. The prostacyclin level in patients without medicationwas approximately 4-fold higher than that of healthy volunteers and 8-foldhigher than those of medicated groups. Although the ratio of the group without medication was similar to that of healthy volunteers, the urinary levels of each prostanoid were higher than those of other groups. Then, the ratios of groups receiving steroids were higher than that of other groups owing to highTX level. The present findings demonstrated that endogenous prostacyclin and thromboxane production increased in patients without medication,and prostacyclin production decreased with medication. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:33:58