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Titolo:
Immunohistochemical localization of the prostacyclin receptor (IP) human bone
Autore:
Fortier, I; Patry, C; Lora, M; Samadfan, R; de Brum-Fernandes, AJ;
Indirizzi:
Univ Sherbrooke, Fac Med, Dept Med, Rheumat Dis Unit, Sherbrooke, PQ, Canada Univ Sherbrooke Sherbrooke PQ Canada at Dis Unit, Sherbrooke, PQ, Canada
Titolo Testata:
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
fascicolo: 2, volume: 65, anno: 2001,
pagine: 79 - 83
SICI:
0952-3278(200108)65:2<79:ILOTPR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN E-2 RECEPTORS; ARACHIDONIC-ACID METABOLISM; OSTEOCLASTIC MOTILITY; CANCELLOUS BONE; CELLS; EXPRESSION; CULTURE; INTERLEUKIN-6; INHIBITION; INCREASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: de Brum-Fernandes, AJ Ctr Univ Sante Estrie, Rheumat Dis Unit, 3001-12 AveNord, Fleurimont, PQ J1H 5N4, Canada Ctr Univ Sante Estrie 3001-12 Ave Nord Fleurimont PQ Canada J1H 5N4
Citazione:
I. Fortier et al., "Immunohistochemical localization of the prostacyclin receptor (IP) human bone", PROS LEUK E, 65(2), 2001, pp. 79-83

Abstract

Prostacyclin (PGI(2)) is an important mediator implicated in bone metabolism. Among the natural prostaglandins it is the most potent inhibitor of bone resorption and mediates bone modelling and remodelling induced by strain changes. The effects of prostacyclin depend on its interaction with a specific receptor (IP). Despite its well documented effects on bone the localization and distribution of the IP receptor in human bone remain unknown. The present study used specific antipeptide antibodies to IP receptor for immunolocalization of the IP receptor in normal, osteoporotic and Pagetic human adult bone and in human fetal bone. The IP receptor was detected in fetal and adult osteoclasts and osteoblasts. Fetal osteocytes also expressed IP receptor but not adult osteocytes. Interestingly, the expression of IP receptor in adult osteoblasts was gradually lost as these cells were trapped in the matrix and became osteocytes. The IP receptor showed a perinuclear distribution within the cells, but in multinuclear osteoclasts not all nuclei were positive. Our results showed differences in IP receptor expression in fetal and adult human bone and, in adult bone, with the differentiation of osteoblasts into osteocytes. They also showed that there is no difference on the expression of prostacyclin receptors in Pagetic, osteoporotic and normal human bone, and they confirm the presence of the IP receptor in human osteoblasts as had been demonstrated by our previous study with human osteoblasts in culture. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 00:55:39