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Titolo:
Adipose tissue and the insulin resistance syndrome
Autore:
Frayn, KN;
Indirizzi:
Radcliffe Infirm, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE & Metab, Oxford OX2 6HE, England
Titolo Testata:
PROCEEDINGS OF THE NUTRITION SOCIETY
fascicolo: 3, volume: 60, anno: 2001,
pagine: 375 - 380
SICI:
0029-6651(200108)60:3<375:ATATIR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; LIPOPROTEIN-LIPASE ACTIVITY; FATTY-ACIDS; PARTIAL LIPODYSTROPHY; POSTPRANDIAL LIPEMIA; ENDOTHELIAL FUNCTION; LIPID-METABOLISM; OBESE SUBJECTS; NORMAL-WEIGHT; HUMAN MUSCLE;
Keywords:
adipose tissue; insulin resistance syndrome; triacylglycerols;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Frayn, KN Radcliffe Infirm, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX2 6HE, England Radcliffe Infirm Oxford England OX2 6HE xford OX2 6HE, England
Citazione:
K.N. Frayn, "Adipose tissue and the insulin resistance syndrome", P NUTR SOC, 60(3), 2001, pp. 375-380

Abstract

Obesity is associated with insulin resistance. Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsivenessof glucose metabolism in other tissues. Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). The net effect is as though adipocytes are 'full up' and resisting further fat storage. Thus, in the postprandial periodespecially, there is an excess flux of circulating lipid metabolites that would normally have been 'absorbed' by adipose tissue. This situation leadsto fat deposition in other tissues. Accumulation of triacylglycerol in skeletal muscles and in liver is associated with insulin resistance. In lipodystrophy there is insufficient adipose tissue to absorb the postprandial influx of fatty acids, so these fatty acids will again be directed to other tissues. This view of the link between adipose tissue and insulin resistance emphasises the important role of adipose tissue in 'buffering' the daily influx of dietary fat entering the circulation and preventing excessive exposure of other tissues to this influx.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:33:29