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Titolo:
Physiological role of adipose tissue: white adipose tissue as an endocrineand secretory organ
Autore:
Trayhurn, P; Beattie, JH;
Indirizzi:
Univ Oslo, Inst Nutr Res, N-0316 Oslo, Norway Univ Oslo Oslo Norway N-0316 iv Oslo, Inst Nutr Res, N-0316 Oslo, Norway Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst Aberdeen Scotland AB21 9SB , Aberdeen AB21 9SB, Scotland
Titolo Testata:
PROCEEDINGS OF THE NUTRITION SOCIETY
fascicolo: 3, volume: 60, anno: 2001,
pagine: 329 - 339
SICI:
0029-6651(200108)60:3<329:PROATW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; RENIN-ANGIOTENSIN SYSTEM; STIMULATING PROTEIN ASP; RECEPTOR MESSENGER-RNA; NECROSIS-FACTOR-ALPHA; OB GENE-EXPRESSION; SYMPATHETIC NERVOUS-SYSTEM; CIRCULATING LEPTIN LEVELS; IN-SITU HYBRIDIZATION; INSULIN-RESISTANCE;
Keywords:
cytokines; fasting-induced adipose factor; leptin; metallothionein; resistin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Trayhurn, P Univ Liverpool, Dept Med, Univ Clin Dept, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA , England
Citazione:
P. Trayhurn e J.H. Beattie, "Physiological role of adipose tissue: white adipose tissue as an endocrineand secretory organ", P NUTR SOC, 60(3), 2001, pp. 329-339

Abstract

The traditional role attributed to white adipose tissue is energy storage,fatty acids being released when fuel is required. The metabolic role of white fat is, however, complex. For example, the tissue is needed for normal glucose homeostasis and a role in inflammatory processes has been proposed. A radical change in perspective followed the discovery of leptin; this critical hormone in energy balance is produced principally by white fat, giving the tissue an endocrine function. Leptin is one of a number of proteins secreted from white adipocytes, which include angiotensinogen, adipsin, acylation-stimulating protein, adiponectin, retinol-binding protein, tumour neorosis factor alpha, interleukin 6, plasminogen activator inhibitor-1 and tissue factor. Some of these proteins are inflammatory cytokines, some play arole in lipid metabolism, while others are involved in vascular haemostasis or the complement system. The effects of specific proteins may be autocrine or paracrine, or the site of action may be distant from adipose tissue. The most recently described adipocyte secretory proteins are fasting-induced adipose factor, a fibrinogen-angiopoietin-related protein, metallothionein and resistin. Resistin is an adipose tissue-specific factor which is reported to induce insulin resistance, linking diabetes to obesity. Metallothionein is a metal-binding and stress-response protein which may have an antioxidant role. The key challenges in establishing the secretory functions of white fat are to identify the complement of secreted proteins, to establishthe role of each secreted protein, and to assess the pathophysiological consequences of changes in adipocyte protein production with alterations in adiposity (obesity, fasting, cachexia). There is already considerable evidence of links between increased production of some adipocyte factors and the metabolic and cardiovascular complications of obesity. In essence, white adipose tissue is a major secretory and endocrine organ involved in a range of functions beyond simple fat storage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:31:56