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Titolo:
Effects of chlorhexidine on human taste perception
Autore:
Frank, ME; Gent, JF; Hettinger, TP;
Indirizzi:
Univ Connecticut, Ctr Hlth, Sch Dent Med, Dept Oral Diag,Div Neurosci, Farmington, CT 06030 USA Univ Connecticut Farmington CT USA 06030 urosci, Farmington, CT 06030 USA
Titolo Testata:
PHYSIOLOGY & BEHAVIOR
fascicolo: 1-2, volume: 74, anno: 2001,
pagine: 85 - 99
SICI:
0031-9384(20010901)74:1-2<85:EOCOHT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHORDA TYMPANI NERVE; GUSTATORY CROSS ADAPTATION; AMILORIDE INHIBITION; VOLTAGE-CLAMP; SODIUM-SALTS; RESPONSES; NACL; QUALITY; RAT; HAMSTER;
Keywords:
human taste perception; salty taste; bitter taste; chlorhexidine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Frank, ME Univ Connecticut, Ctr Hlth, Sch Dent Med, Dept Oral Diag,Div Neurosci, Taste & Smell Ctr MC 1718,263 Farmington Ave, Farmington, CT 06030 USA Univ Connecticut Taste & Smell Ctr MC 1718,263 Farmington Ave FarmingtonCT USA 06030
Citazione:
M.E. Frank et al., "Effects of chlorhexidine on human taste perception", PHYSL BEHAV, 74(1-2), 2001, pp. 85-99

Abstract

Chlorhexidine, a bis-cationic biguanide antiseptic, greatly reduces the perceived intensity of the salty prototype sodium chloride and may prove to be an important probe of mechanisms that underlie the human salty taste quality, Chlorhexidine, which tastes bitter, also reduces quinine hydrochloridetaste intensity, but neither sweet sucrose nor sour citric acid is affected. Perceptual intensity rating and quality identification were measured forhuman subjects before and for 30 min following treatment with 1.34 mM chlorhexidine gluconate. In one experiment, test stimuli were the taste-qualityprototypes; in a second experiment, stimuli were series of sodium, halide and sulfate salts. Experiment 1 showed a single 3-min chlorhexidine treatment resulted in reductions in taste intensity that persisted for at least 30min. Experiment 2 showed a single 2-min chlorhexidine treatment reduced perceptual intensities of halide and sulfate salts except those with divalentcations. Chlorhexidine impaired identification of the salty quality and produced a bitter quality in nonbitter salts and impaired identification of the bitter quality of quinine, but not bitter salts. The specific effect of chlorhexidine on the bitterness of quinine suggests it may bind to the samereceptor as quinine. The ability of chlorhexidine to specifically disrupt saltiness of a wide range of salts is consistent with proposed peripheral transduction mechanisms for the salty quality that involve transepithelial ion transport. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:07:01