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Titolo:
Pet in psychopharmacology
Autore:
Moresco, RM; Messa, C; Lucignani, G; Rizzo, G; Todde, S; Gilardi, MC; Grimaldi, A; Fazio, F;
Indirizzi:
Univ Milan Bicocca, HS Raffaele, Dept Nucl Med, CNR,INB, I-20132 Milan, Italy Univ Milan Bicocca Milan Italy I-20132 ed, CNR,INB, I-20132 Milan, Italy Univ Milan, Milan, Italy Univ Milan Milan ItalyUniv Milan, Milan, Italy
Titolo Testata:
PHARMACOLOGICAL RESEARCH
fascicolo: 3, volume: 44, anno: 2001,
pagine: 151 - 159
SICI:
1043-6618(200109)44:3<151:PIP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO EVALUATION; STRIATAL DOPAMINE RELEASE; RECEPTOR-BINDING; F-18 SETOPERONE; ANTIDEPRESSANT TREATMENT; SEROTONIN(2) RECEPTORS; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; MAJOR DEPRESSION;
Keywords:
emission tomography; drug development; psychiatric diseases; neurochemistry; tracer;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Moresco, RM Univ Milan Bicocca, HS Raffaele, Dept Nucl Med, CNR,INB, I-20132 Milan, Italy Univ Milan Bicocca Milan Italy I-20132 I-20132 Milan, Italy
Citazione:
R.M. Moresco et al., "Pet in psychopharmacology", PHARMAC RES, 44(3), 2001, pp. 151-159

Abstract

Emission tomography techniques and, in particular, positron emission tomography (PET) enable the in vivo study of several physiological and neurochemical variables in human subjects using methods originally developed for quantitative autoradiography. In particular, PET allows one to evaluate in human subjects: (a) the effect of specific neurochemical challenges on regional brain function at rest or under activation; (b) the activity of neurotransmitters and the regional expression of specific molecular targets during pathology including their modulation by drug treatment;, (c) the kinetics ofdrug disposition and activity directly in the target organ. This is of primary interest in the field of biological psychiatry and in psychoactive drugs development, where it is particularly difficult to reproduce human diseases using animal models in view of the peculiarity of this field and the large heterogeneity of each psychiatric illness also inside the same clinicaldefinition. The aim of this paper is to review the principal strategies and the main results of the use of PET in psychopharmacology. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:39:52