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Titolo:
Influence of octreotide on liver metastasis and hepatic lipid peroxidationin BOP-induced pancreatic cancer in Syrian hamsters
Autore:
Wenger, FA; Kilian, M; Mautsch, I; Jacobi, CA; Steiert, A; Peter, FJ; Guski, H; Schimke, I; Muller, JM;
Indirizzi:
Humboldt Univ, Dept Gen Visceral Vasc & Thorac Surg, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 horac Surg, D-10098 Berlin, Germany Humboldt Univ, Inst Pathol, D-10098 Berlin, Germany Humboldt Univ BerlinGermany D-10098 nst Pathol, D-10098 Berlin, Germany Humboldt Univ, Dept Internal Med 1, D-10098 Berlin, Germany Humboldt UnivBerlin Germany D-10098 rnal Med 1, D-10098 Berlin, Germany
Titolo Testata:
PANCREAS
fascicolo: 3, volume: 23, anno: 2001,
pagine: 266 - 272
SICI:
0885-3177(200110)23:3<266:IOOOLM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AZASERINE-TREATED RATS; HIGH-FAT DIET; OXYGEN-FREE RADICALS; FISH-OIL MAXEPA; ARACHIDONIC-ACID; CARCINOGENESIS; SOMATOSTATIN; GROWTH; CHOLECYSTOKININ; ADENOCARCINOMA;
Keywords:
octreotide; pancreatic cancer; liver metastasis; lipidperoxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Wenger, FA Humboldt Univ, Dept Gen Visceral Vasc & Thorac Surg, Charite Campus Mitte,Schumannstr 20-21, D-10098 Berlin, Germany Humboldt Univ ChariteCampus Mitte,Schumannstr 20-21 Berlin Germany D-10098
Citazione:
F.A. Wenger et al., "Influence of octreotide on liver metastasis and hepatic lipid peroxidationin BOP-induced pancreatic cancer in Syrian hamsters", PANCREAS, 23(3), 2001, pp. 266-272

Abstract

Introduction: In prospective clinical trials, octreotide improved quality of life and survival time in patients with pancreatic cancer. Aims: To analyze whether octreotide modulates the hepatic oxygen radical metabolism and thus might decrease liver metastasis in an animal model of pancreatic cancer. Methodology: Syrian hamsters received 0.9% NaCl or N-nitrosobis(2-oxopropyl)amine (BOP) for 3 months. Therapy was performed for 12 weeks by 0.9% NaClor octreotide. Hamsters received a standard diet (3.5% fat) or were fed a high-fat diet (21.4% fat). In the 25th week, the pancreas and liver were examined macroscopically and histologically. The level of lipid peroxidation and activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were determined intrahepatically. Results: The number of liver metastases per animal and the size of liver metastases Were increased by the high-fat diet, whereas they were decreased by octreotide. Octreotide increased activities of GSH-Px and SOD. The concentration of thiobarbituric acid reactive substances was increased by BOP and a high-fat diet and decreased by octreotide. Conclusion: Octreotide decreases the number and size of liver metastases in chemically induced pancreatic cancer in Syrian hamsters. This is accompanied by high hepatic GSH-Px and SOD activity and a low level of lipid peroxidation.

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Documento generato il 05/12/20 alle ore 18:45:36