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Titolo:
Determination of the median effective concentration (EC50) of propofol during oesophagogastroduodenoscopy in children
Autore:
Hammer, GB; Litalien, C; Wellis, V; Drover, DR;
Indirizzi:
Stanford Univ, Med Ctr, Dept Anesthesia H3580, Sch Med, Stanford, CA 94305USA Stanford Univ Stanford CA USA 94305 H3580, Sch Med, Stanford, CA 94305USA Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Pediat, Stanford, CA 94305 USA Ctr Hosp Univ Quebec, Dept Paediat, Quebec City, PQ, Canada Ctr Hosp Univ Quebec Quebec City PQ Canada diat, Quebec City, PQ, Canada
Titolo Testata:
PAEDIATRIC ANAESTHESIA
fascicolo: 5, volume: 11, anno: 2001,
pagine: 549 - 553
SICI:
1155-5645(200109)11:5<549:DOTMEC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER GASTROINTESTINAL ENDOSCOPY; ISOFLURANE-NITROUS OXIDE; CONTROLLED INFUSION; GENERAL-ANESTHESIA; SEDATION; PHARMACOKINETICS; THIOPENTONE; MIDAZOLAM; INDUCTION; SEVOFLURANE;
Keywords:
propofol for endoscopy; propofol in children; target-controlled infusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hammer, GB Stanford Univ, Med Ctr, Dept Anesthesia H3580, Sch Med, Stanford, CA 94305USA Stanford Univ Stanford CA USA 94305 Med, Stanford, CA 94305USA
Citazione:
G.B. Hammer et al., "Determination of the median effective concentration (EC50) of propofol during oesophagogastroduodenoscopy in children", PAEDIATR AN, 11(5), 2001, pp. 549-553

Abstract

Background: Propofol is commonly used to provide anaesthesia for children undergoing oesophagogastroduodenoscopy (OGD). Despite this, the plasma concentration-response relationships for propofol used in this setting have notbeen established. Methods: In order to determine the EC50 of propofol during OGD, we studied12 children aged 3-10 years. No premedication was given. Propofol was administered via a target-controlled infusion system using the STANPUMP software based on a paediatric pharmacokinetic model. The 'up-and-down' method described by Dixon was used to determine the EC50. Accordingly, the target plasma propofol concentration for each patient, beginning with the second subject, was determined by the response of the previous patient. A patient was considered a 'responder' if there was minimal movement and the heart rate (HR) and blood pressure (BP) remained less than or equal to 120% of baselineduring the procedure. Patients who moved excessively, i.e. requiring more than gentle restraint, or who manifest HR and BP >120% of baseline, were considered 'nonresponders'. Results: The EC50 of propofol during OGD was 3.55 mug.ml(-1) in this study. Conclusions: The plasma propofol concentration associated with adequate anaesthesia for OGD in 50% of unpremedicated children is 3.55 mug-ml(-1). This concentration is higher than that required for OGD in adult patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:56:45