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Titolo:
Induction of FGF receptor 2-IIIb expression and response to its ligands inepithelial ovarian cancer
Autore:
Steele, IA; Edmondson, RJ; Bulmer, JN; Bolger, BS; Leung, HY; Davies, BR;
Indirizzi:
Univ Newcastle Upon Tyne, Sch Med, Dept Surg, Newcastle Upon Tyne NE2 4HH,Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE2 4HH Royal Victoria Infirm, Dept Pathol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE2 4HH and Queen Elizabeth Hosp, No Gynaecol Oncol Ctr, Gateshead, Tyne & Wear, England Queen Elizabeth Hosp Gateshead Tyne & Wear England Tyne & Wear, England Royal Victoria Infirm, Dept Obstet & Gynaecol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE2 4HH and
Titolo Testata:
ONCOGENE
fascicolo: 41, volume: 20, anno: 2001,
pagine: 5878 - 5887
SICI:
0950-9232(20010913)20:41<5878:IOFR2E>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; E-CADHERIN EXPRESSION; SURFACE EPITHELIUM; PROSTATE-CANCER; CELLS; KERATINOCYTE; FAMILY; SPECIFICITY; CARCINOMAS; TISSUES;
Keywords:
FGF receptor 2; ovarian cancer; ovarian surface epithelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Davies, BR Univ Newcastle Upon Tyne, Sch Med, Dept Surg, Newcastle Upon Tyne NE2 4HH,Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE2 4HH
Citazione:
I.A. Steele et al., "Induction of FGF receptor 2-IIIb expression and response to its ligands inepithelial ovarian cancer", ONCOGENE, 20(41), 2001, pp. 5878-5887

Abstract

Epithelial ovarian cancers (EOCs) arise in the Ovarian Surface Epithelium (OSE). This tissue is a simple, poorly committed mesothelium which exhibitscharacteristics of epithelial and mesenchymal cells when grown in culture. In contrast, EOCs frequently exhibit properties of complex epithelial tissues of the female reproductive tract, such as oviductal, endometrial and cervical epithelia, and show induction of expression of epithelial markers such as E-cadherin. Fibroblast Growth Factor Receptor 2 isoform IIIb (FGF receptor 2-IIIb) is a spliced variant of FGF receptor 2 that binds the ligandsFGF-1 and FGF-7 with high affinity, and is expressed exclusively by epithelial cells. We have studied the expression of FGF receptor 2-IIIb and its ligands in primary cultures of normal human OSE, EOC cell lines and snap frozen tissue from EOCs. Expression of FGF receptor 2-IIIb mRNA is undetectable in normal OSE, but is expressed in 16/20 (80%) of EOCs. FGFs 1 and 7 mRNAs are expressed in normal OSE, whilst only 4/20 (20%) and 12/20 (60%) of EOCs demonstrated expression for these ligands respectively. However, FGF-7 protein was detected in 70% (mean level = 0.7 ng/ml) of ascitic fluids obtained from patients with EOC. FGFs 1 and 7 stimulate DNA synthesis in EOC cell lines that express FGF receptor 2-IIlb. Moreover, DNA synthesis in these cell lines can be partially blocked by blocking antisera to FGFs 1 and 7. It is suggested that induction of expression of FGF receptor 2-IIIb may playa role in the development of EOCs by rendering the OSE susceptible to paracrine and/or autocrine stimulation by its requisite FGF ligands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:48:12