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Titolo:
Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitorof apoptosis
Autore:
Aouacheria, A; Arnaud, E; Venet, S; Lalle, P; Gouy, M; Rigal, D; Gillet, G;
Indirizzi:
Univ Lyon 1, CNRS, UMR 5086, Inst Biol & Chim Prot, F-69367 Lyon 07, France Univ Lyon 1 Lyon France 07 nst Biol & Chim Prot, F-69367 Lyon 07, France Univ Lyon 1, CNRS, UMR 5558, F-67622 Villeurbanne, France Univ Lyon 1 Villeurbanne France F-67622 58, F-67622 Villeurbanne, France Etablissement Transfus Sanguine, F-69007 Lyon, France Etablissement Transfus Sanguine Lyon France F-69007 F-69007 Lyon, France
Titolo Testata:
ONCOGENE
fascicolo: 41, volume: 20, anno: 2001,
pagine: 5846 - 5855
SICI:
0950-9232(20010913)20:41<5846:NAHHON>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
OUTER MITOCHONDRIAL-MEMBRANES; CELL-DEATH; CYTOCHROME-C; BH3 DOMAIN; ANTIAPOPTOTIC BCL-2; BCL-2-RELATED GENE; AVIAN CELLS; ION-CHANNEL; IN-VITRO; BAX;
Keywords:
apoptosis; molecular cloning; Bcl-2 family; phylogeny;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Gillet, G Univ Lyon 1, CNRS, UMR 5086, Inst Biol & Chim Prot, 7 Passage Vercors, F-69367 Lyon 07, France Univ Lyon 1 7 Passage Vercors Lyon France 07 67 Lyon 07, France
Citazione:
A. Aouacheria et al., "Nrh, a human homologue of Nr-13 associates with Bcl-Xs and is an inhibitorof apoptosis", ONCOGENE, 20(41), 2001, pp. 5846-5855

Abstract

In search of human homologues of the anti-apoptotic protein Nr-13, we havecharacterized a human EST clone that potentially encodes a protein, which is the closest homologue of Nr-13 among the Bcl-2 family members, to date known, in humans. Phylogenetic analyses suggest Human nrh, Mouse diva/boo and Quail nr-13 to be orthologous genes. The nrh gene has the same overall organization as nr-13 and diva/boo with one single intron interrupting the ORF at the level of the Bcl-2-homology domain BH2. RT-PCR-based analysis of nrh expression indicated that this gene is preferentially expressed in the lungs, the liver and the kidneys. Interestingly, two in frame ATG codons canlead potentially to the synthesis of two products, one of them lacking 10 aminoacids at the N-terminal end. Sequence alignment with nr-13 and Diva/Boo in addition to secondary structure prediction of the nrh transcript suggested that the shortest protein will be preferentially synthetized. Immunohistochemical analyses have revealed that Nrh is associated with mitochondriaand the nuclear envelope. Moreover, Nrh preferentially associates with theapoptosis accelerator Bcl-Xs and behaves as an inhibitor of apoptosis bothin yeast and vertebrate cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:01:57