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Titolo:
Synthesis of certain 2 '-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5 '; Evaluation as potential dUTP analogues
Autore:
Marriott, JH; Aherne, GW; Hardcastle, A; Jarman, M;
Indirizzi:
Inst Canc Res, Canc Res Campaign, Ctr Canc Therapeut, Sutton SM2 5NG, Surrey, England Inst Canc Res Sutton Surrey England SM2 5NG tton SM2 5NG, Surrey, England
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 9, volume: 20, anno: 2001,
pagine: 1691 - 1704
SICI:
1525-7770(2001)20:9<1691:SOC2'D>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE; INHIBITORS; ENZYME; SERIES; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Jarman, M Inst Canc Res, Canc Res Campaign, Ctr Canc Therapeut, 15 Cotswold Rd, Sutton SM2 5NG, Surrey, England Inst Canc Res 15 Cotswold Rd Sutton Surrey England SM2 5NG gland
Citazione:
J.H. Marriott et al., "Synthesis of certain 2 '-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5 '; Evaluation as potential dUTP analogues", NUCLEOS NUC, 20(9), 2001, pp. 1691-1704

Abstract

Derivatives of 2 ' -deoxyuridine in which the 5 ' -OH group is replaced bya 2,3,6-trifluoro-5-hydroxy-4-nitrophenoxy or a 4-carboxy-2,3,6-trifluoro-5-hydroxyphenoxy group have been prepared for evaluation as possible dUTP analogues. They showed a weak ability to displace radiolabelled dUTP from a dUTP-binding antiserum. The corresponding compounds lacking the three fluorine substituents were prepared for comparison.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:05:41