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Titolo:
Synthesis of 5-alkenylated d4T analogues via the Pd-catalyzed cross-coupling reaction
Autore:
Ciurea, A; Fossey, C; Benzaria, S; Gavriliu, D; Delbederi, Z; Lelong, B; Laduree, D; Aubertin, AM; Kirn, A;
Indirizzi:
Univ Caen, UFR Sci Pharmaceut, Ctr Etud & Rech Med Normandie, F-14032 Caen, France Univ Caen Caen France F-14032 & Rech Med Normandie, F-14032 Caen, France INSERM, F-67000 Strasbourg, France INSERM Strasbourg France F-67000INSERM, F-67000 Strasbourg, France
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 9, volume: 20, anno: 2001,
pagine: 1655 - 1670
SICI:
1525-7770(2001)20:9<1655:SO5DAV>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOSIDE ANALOGS; ANTIVIRAL ACTIVITY; VIRUS TYPE-1; DERIVATIVES; DNA; AGENTS; C-5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Laduree, D Univ Caen, UFR Sci Pharmaceut, Ctr Etud & Rech Med Normandie, 5Rue Vaubenard, F-14032 Caen, France Univ Caen 5 Rue Vaubenard Caen FranceF-14032 032 Caen, France
Citazione:
A. Ciurea et al., "Synthesis of 5-alkenylated d4T analogues via the Pd-catalyzed cross-coupling reaction", NUCLEOS NUC, 20(9), 2001, pp. 1655-1670

Abstract

The target compounds 5-[N-(6-amino-hexyl)-acrylamide]-2 ' ,3 ' -didehydro-2 ' ,3 ' -dideoxy-uridine (12) and 5-{N-[5-(methoxycarbonyl)-pentyl]acrylamide}-2 ' ,3 ' -didehydro-2',3 ' -dideoxy-uridine (15) were prepared by the palladium acetate-triphenylphosphine-catalyzed reaction of the 5 ' -O-acetyl-5-iodo-d4T analogue (3). These compounds 12 and 15 can be used to preparenucleotide probes carrying fluorescent labels and were nevertheless screened for their anti-HIV activity. The biological data demonstrated that none of them were active against HIV-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:24:42