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Titolo:
Thiosugars. VIII. Preparation of new 41-thio-L-lyxo pyrimidine nucleoside analogues
Autore:
Wirsching, J; Voss, J; Adiwidjaja, G; Balzarini, J; De Clercq, E;
Indirizzi:
Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany Univ Hamburg Hamburg Germany D-20146 rgan Chem, D-20146 Hamburg, Germany Univ Hamburg, Mineral Petrog Inst, D-20146 Hamburg, Germany Univ Hamburg Hamburg Germany D-20146 trog Inst, D-20146 Hamburg, Germany Catholic Univ Louvain, Rega Inst Med Res, B-3000 Louvain, Belgium CatholicUniv Louvain Louvain Belgium B-3000 es, B-3000 Louvain, Belgium
Titolo Testata:
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
fascicolo: 9, volume: 20, anno: 2001,
pagine: 1625 - 1645
SICI:
1525-7770(2001)20:9<1625:TVPON4>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOLOGICAL-ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Voss, J Univ Hamburg, Inst Organ Chem, Martin Luther King Pl 6, D-20146 Hamburg, Germany Univ Hamburg Martin Luther King Pl 6 Hamburg Germany D-20146 many
Citazione:
J. Wirsching et al., "Thiosugars. VIII. Preparation of new 41-thio-L-lyxo pyrimidine nucleoside analogues", NUCLEOS NUC, 20(9), 2001, pp. 1625-1645

Abstract

Reaction of 1-O-acetyl-2,3,5-tri-O-benzyl-4-thio-L-lyxofuranose with silylated pyrimidine bases and subsequent deprotection with boron tribromide ledto 4 ' -thio-L-lyxo pyrimidine nucleosides. The 5-bromo-6methyl derivativewas prepared from methyl 2,3,5-tri-O-acetyl-4-thio-L-lyxofuranoside. Deacetylation was performed with sodium methoxide. The anomers were separated byHPLC and their configurations assigned by NMR spectroscopy and X-ray structural analyses. The biological activity of the nucleosides was tested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:18:05