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Titolo:
Interleukin-10
Autore:
Narula, S; Cuss, F;
Indirizzi:
Schering Plough Corp, Res Inst, Dept Immunol & Allergy Drug Discovery, Kenilworth, NJ 07033 USA Schering Plough Corp Kenilworth NJ USA 07033 ry, Kenilworth, NJ 07033 USA
Titolo Testata:
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
, volume: 31, anno: 2001,
pagine: 269 - 273
SICI:
1422-2140(2001)31:<269:I>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT HUMAN INTERLEUKIN-10; TUMOR-NECROSIS-FACTOR; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; INHIBITS CYTOKINE PRODUCTION; CD4(+) T-CELLS; CYSTIC-FIBROSIS; IFN-GAMMA; PSEUDOMONAS-AERUGINOSA; LETHAL ENDOTOXEMIA; IL-10 RECEPTOR;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Narula, S Schering Plough Corp, Res Inst, Dept Immunol & Allergy Drug Discovery, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA Schering Plough Corp 2015 Galloping Hill Rd Kenilworth NJ USA 07033
Citazione:
S. Narula e F. Cuss, "Interleukin-10", PROG R RES, 31, 2001, pp. 269-273

Abstract

Accumulating data suggest that several inflammatory respiratory diseases, such as asthma and cystic fibrosis, are associated with IL-10 deficiency. There is strong evidence from animal studies that endogenous IL-10 has an important immunoregulatory role in suppressing excessive inflammation in the lung. Regardless of the etiological role of IL-10 deficiency, there is little question that production of proinflammatory cytokines, such as IL-1, TNF, IL-6 and IL-8 is directly related to acute and chronic morbidity in many lung diseases. Thus, the effects of IL-10 may provide a physiological form of anti-inflammatory therapy which may ameliorate the morbidity of respiratory disease. Other activities of IL-10, particularly its potential antifibrotic effect, may offer other long term benefits. It is possible that local administration of IL-10 to the lung will be required for its full effectiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:15:11