Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Recombinant allergens
Autore:
Valenta, R; Kraft, D;
Indirizzi:
Univ Vienna, Dept Pathophysiol, AKH, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 hophysiol, AKH, A-1090 Vienna, Austria
Titolo Testata:
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
, volume: 31, anno: 2001,
pagine: 195 - 200
SICI:
1422-2140(2001)31:<195:RA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIRCH POLLEN ALLERGEN; STRUCTURAL SIMILARITIES; MAJOR ALLERGEN; IGE-BINDING; HAZEL; IMMUNOTHERAPY; DERIVATIVES; ANTIBODIES; COMPONENT; EPITOPES;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Valenta, R Univ Vienna, Dept Pathophysiol, AKH, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 stria
Citazione:
R. Valenta e D. Kraft, "Recombinant allergens", PROG R RES, 31, 2001, pp. 195-200

Abstract

An increasing number of hypoallergenic allergen derivatives is currently being produced by genetic engineering as well as by synthetic peptide chemistry and evaluated as candidate molecules for specific immunotherapy of typeI allergy. One advantage of recombinant and synthetic hypoallergenic allergen derivatives is that they can be designed to simultaneously retain the immunogenic/tolerogenic properties of the wild-type allergens and to exhibita strongly reduced allergenic activity, When used for immunotherapy, it may be expected that hypoallergenic allergen derivatives will exhibit a lowerrate of anaphylactic side effects. Furthermore, hypoallergenic allergen derivatives can be used for component-resolved immunotherapy tailored according to the individual patient's sensitization profile. This chapter summarizes strategies for the production and evaluation of recombinant as well as of synthetic hypoallergenic allergen derivatives as candidate vaccines for type I allergy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:35:19