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Titolo:
Allergen, IgE and mast-cell-directed therapies: An overview
Autore:
Larche, M; Kay, AB;
Indirizzi:
Natl Heart & Lung Inst, Imperial Coll, Sch Med, Dept Allergy & Clin Immunol, London SW3 6LY, England Natl Heart & Lung Inst London England SW3 6LY l, London SW3 6LY, England
Titolo Testata:
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
, volume: 31, anno: 2001,
pagine: 182 - 185
SICI:
1422-2140(2001)31:<182:AIAMTA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUST MITE ALLERGEN; FEL-D-1 PEPTIDES; SERUM LEVELS; T-CELLS; IMMUNOTHERAPY; CD23; ANTIBODIES; EFFICACY; BINDING; ASTHMA;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Larche, M Natl Heart & Lung Inst, Imperial Coll, Sch Med, Dept Allergy & Clin Immunol, Dovehouse St, London SW3 6LY, England Natl Heart & Lung Inst Dovehouse St London England SW3 6LY land
Citazione:
M. Larche e A.B. Kay, "Allergen, IgE and mast-cell-directed therapies: An overview", PROG R RES, 31, 2001, pp. 182-185

Abstract

In addition to traditional drug development strategies, a number of current approaches focus on modulation of the immune response to allergens or, the allergens themselves. Disease-modulating specific immunotherapy has been used for many years and has been shown to be efficacious, although this form of treatment is slow and carries the risk of systemic adverse reactions. The identification of naturally occurring allergen isoforms of the native protein which do not bind IgE has led to modification of a number of allergens by site-directed mutagenesis. Such proteins have a reduced or absent interaction with IgE whilst retaining much of their ability to stimulate T cells. The improved safety profile of such molecules may result in larger, more efficacious doses of protein being given with improved safety. Fragments of allergen molecules, such as peptides, are also under development, employing a similar rationale of destroying IgE binding epitopes whilst retainingT cell determinants. Neutralization of specific molecules in the inflammatory cascade is currently being addressed with 'humanized' monoclonal antibodies and soluble receptors/ receptor antagonists, directed towards IgE, cytokines such as IL-4 and IL-5, and cell surface molecules such as CD23.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 11:43:49