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Titolo:
Tryptase inhibition
Autore:
Clark, JM; Van Dyke, RE; Kurth, MC;
Indirizzi:
Axys Pharmaceut Inc, S San Francisco, CA 94080 USA Axys Pharmaceut Inc S San Francisco CA USA 94080 Francisco, CA 94080 USA
Titolo Testata:
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
, volume: 31, anno: 2001,
pagine: 170 - 172
SICI:
1422-2140(2001)31:<170:TI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELL TRYPTASE; PROTEASE INHIBITORS; HISTAMINE-RELEASE; FIBROBLASTS; MITOGEN; AIRWAY; MODULATION; RECEPTORS; COLLAGEN; SHEEP;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Clark, JM Axys Pharmaceut Inc, 180 Kimball Way, S San Francisco, CA 94080 USA Axys Pharmaceut Inc 180 Kimball Way S San Francisco CA USA 94080
Citazione:
J.M. Clark et al., "Tryptase inhibition", PROG R RES, 31, 2001, pp. 170-172

Abstract

Tryptase, a mast-cell-specific serine protease, has been used for a numberof years as a marker of mast cell activation. Elevated levels of the enzyme have been detected in allergic diseases including asthma, conjunctivitis and rhinitis, and in some diseases in which mast cell mediators have been hypothesized to play a role, such as rheumatoid arthritis, inflammatory bowel disease and interstitial cystitis. In the case of asthma, numerous studies suggested a role for tryptase in the underlying pathology of the disease. APC 366, a small molecule inhibitor of tryptase, has shown efficacy in vivo, thus confirming a causal role for tryptase in experimental models of allergic asthma. In recent phase II clinical trials, APC 366 has demonstrated efficacy in patients with mild to moderate asthma. Together, these data provide a compelling rationale for the development of tryptase inhibitors withgreater potency and selectivity for the treatment of asthma and other allergic diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:23:11