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Titolo:
Kinin receptor antagonists
Autore:
Meini, S; Maggi, CA;
Indirizzi:
Menarini Ric SpA, Dept Pharmacol, I-50131 Florence, Italy Menarini Ric SpA Florence Italy I-50131 armacol, I-50131 Florence, Italy
Titolo Testata:
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
, volume: 31, anno: 2001,
pagine: 137 - 140
SICI:
1422-2140(2001)31:<137:KRA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRADYKININ-INDUCED BRONCHOCONSTRICTION; GUINEA-PIGS; MICROVASCULAR LEAKAGE; PLASMA EXTRAVASATION; CHEMOTACTIC ACTIVITY; RELEASE NEUTROPHIL; B-2 RECEPTORS; NITRIC-OXIDE; HYPERRESPONSIVENESS; TACHYKININS;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Maggi, CA Menarini Ric SpA, Dept Pharmacol, Via Rismondo 12A, I-50131 Florence, Italy Menarini Ric SpA Via Rismondo 12A Florence Italy I-50131 Italy
Citazione:
S. Meini e C.A. Maggi, "Kinin receptor antagonists", PROG R RES, 31, 2001, pp. 137-140

Abstract

Kinins are small peptides which are produced in the blood or tissues during inflammation. They act by stimulating distinct receptors, B-1 and B-2. The B-1 receptor is induced during inflammation whereas the B-2 receptor is constitutively expressed. Kinins produce a number of effects which are relevant for airway pathophysiology (bronchoconstriction, plasma protein extravasation, mucus secretion, stimulation of inflammatory cells). It is currently proposed that kinin receptor antagonists could represent a novel class ofdrugs useful for the treatment of chronic airway diseases, including asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:01:27