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Titolo:
Histamine H-3 antagonists
Autore:
McLeod, RL; Egan, RW; Cuss, FM; Bolser, DC; Hey, JA;
Indirizzi:
Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA Schering Plough Corp Kenilworth NJ USA 07033 st, Kenilworth, NJ 07033 USA
Titolo Testata:
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
, volume: 31, anno: 2001,
pagine: 133 -
SICI:
1422-2140(2001)31:<133:HHA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; ALLERGIC RHINITIS; NASAL CONGESTION; INHIBITION; RECEPTOR; RESPONSES; H3-RECEPTORS; ACTIVATION; RELEASE; MODEL;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: McLeod, RL Schering Plough Corp, Res Inst, 2015 Galloping Hill Rd, Kenilworth, NJ 07033 USA Schering Plough Corp 2015 Galloping Hill Rd Kenilworth NJUSA 07033
Citazione:
R.L. McLeod et al., "Histamine H-3 antagonists", PROG R RES, 31, 2001, pp. 133

Abstract

Treatment of allergic rhinitis often involves the use of H-1 antihistamines which block histamine, a primary mediator in allergic responses. Antihistamines alone do not provide significant benefit against the congestion associated with allergic rhinitis and are commonly given in combination with a-adrenergic decongestants. Whereas these decongestants are effective in reducing th congestion associated with allergic nasal disease, they may produceundesirable side effects, such as hypertension, agitation and insomnia. Presently, we discuss preclinical findings showing that combination histamineH-1 and H-3 receptor blockade produces decongestant activity without the hypertensive liability characteristic of a-adrenoceptor agonists.

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Documento generato il 24/01/21 alle ore 04:15:35