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Titolo:
Clinical studies on new drugs
Autore:
Hansel, TT; Barnes, PJ;
Indirizzi:
Royal Brompton Hosp, NHLI, Clin Studies Unit, London SW3 6HP, England Royal Brompton Hosp London England SW3 6HP Unit, London SW3 6HP, England
Titolo Testata:
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
, volume: 31, anno: 2001,
pagine: 48 - 51
SICI:
1422-2140(2001)31:<48:CSOND>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; PLACEBO-CONTROLLED TRIAL; INHALED BUDESONIDE; TIOTROPIUM BROMIDE; ASTHMATIC SUBJECTS; RESPONSES; MILD; ANTIBODY; COPD; CORTICOSTEROIDS;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hansel, TT Royal Brompton Hosp, NHLI, Clin Studies Unit, Fulham Rd, LondonSW3 6HP, England Royal Brompton Hosp Fulham Rd London England SW3 6HP , England
Citazione:
T.T. Hansel e P.J. Barnes, "Clinical studies on new drugs", PROG R RES, 31, 2001, pp. 48-51

Abstract

The incidence of both asthma and COPD is increasing throughout the world, and acts as a major incentive for the development of improved therapy. For the large range of bronchodilator and antiinflammatory therapies in currentclinical development, reliable decision making is required in phase IT, before entering large-scale and expensive phase III studies. With anti-inflammatory therapies for asthma, there has been a tendency to move away from the inhaled-allergen challenge as a proof of concept study, and instead test in symptomatic clinical disease in conjunction with biomarkers. Phase II studies in COPD are more difficult because inclusion criteria, monitoring parameters, comparator therapies and trial design are less well established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:00:30