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Titolo:
Immunopathology: Comparison of COPD and asthma
Autore:
Jeffery, PK;
Indirizzi:
Natl Heart & Lung Inst, Imperial Coll Sch Med, London, England Natl Heart & Lung Inst London England ial Coll Sch Med, London, England
Titolo Testata:
NEW DRUGS FOR ASTHMA, ALLERGY AND COPD
, volume: 31, anno: 2001,
pagine: 24 - 29
SICI:
1422-2140(2001)31:<24:ICOCAA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; AIR-FLOW OBSTRUCTION; CHRONIC-BRONCHITIS; PERIPHERAL AIRWAYS; CIGARETTE SMOKERS; T-LYMPHOCYTES; INFLAMMATION; LUNGS; EMPHYSEMA; SMOKING;
Tipo documento:
Article
Natura:
Collana
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Jeffery, PK Royal Brompton Hosp, Lung Pathol Unit, Sydney St, London SW3 6NP, England Royal Brompton Hosp Sydney St London England SW3 6NP England
Citazione:
P.K. Jeffery, "Immunopathology: Comparison of COPD and asthma", PROG R RES, 31, 2001, pp. 24-29

Abstract

Both COPD and asthma are not disease entities, but rather each is a complex of conditions contributing to airflow obstruction. Three conditions may contribute to airflow limitation in COPD; (1) chronic bronchitis (mucous hypersecretion); (2) adult chronic bronchiolitis (small or peripheral airways disease) and (3) emphysema (defined anatomically by permanent, destructive enlargement of airspaces distal to terminal bronchioli without obvious fibrosis). The airways in chronic bronchitis and in COPD are markedly inflamed;however, in contrast to asthma, the predominant type of inflammatory cell and the main anatomic site of the lesion appear to differ. There is difficulty distinguishing subjects with COPD who may show a degree of reversibility and those older subjects with asthma whose reversible airflow obstructionhas become more 'fixed'; moreover, mixtures of COPD and asthma may coexistin any one patient (fig. 1). The following synopsis focuses on the structural changes and the inflammation of conducting airways and lung in COPD andbriefly makes comparisons with what is known in asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:20:03