Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Correlation between local glucose transporter densities and local 3-O-methylglucose transport in rat brain
Autore:
Duelli, R; Maurer, MH; Staudt, R; Sokoloff, L; Kuschinsky, W;
Indirizzi:
Univ Heidelberg, Dept Physiol & Pathophysiol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany NIMH, Cerebral Metab Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 MH, Cerebral Metab Lab, Bethesda, MD 20892 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 310, anno: 2001,
pagine: 101 - 104
SICI:
0304-3940(20010914)310:2-3<101:CBLGTD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUT3; NEURONS; PROTEINS; BARRIER;
Keywords:
glucose transporter; Glut1; Glut3; local cerebral transport rates; autoradiography; 3-O-methylglucose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Duelli, R Univ Heidelberg, Dept Physiol & Pathophysiol, Neuenheimer Feld 326, D-69120 Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 326 Heidelberg Germany D-69120
Citazione:
R. Duelli et al., "Correlation between local glucose transporter densities and local 3-O-methylglucose transport in rat brain", NEUROSCI L, 310(2-3), 2001, pp. 101-104

Abstract

The present study addresses the question whether local glucose transport kinetics are correlated with local glucose transporter densities in the brain. In 47 brain structures the local rate constants for 3- O-[C-14] methylglucose (3-O-MG) transport, K-1 and k(2), were quantified, and local glucose Glut1 and Glut3 transporter densities were determined by immuno-autoradiographic methods. Statistically significant correlations were found between the rate constants for glucose transport and the transporter densities. The correlations were tighter for Glut1 than for Glut3. Inasmuch as 3-O-MG is transported by the same transporter as glucose, these results indicate that the local densities of glucose transporters determine local glucose transport rates in the brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 00:32:26