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Titolo:
Intracerebroventricular injection of pipecolic acid inhibits food intake and induces sleeping-like behaviors in the neonatal chick
Autore:
Takagi, T; Ando, R; Ohgushi, A; Yamashita, T; Dobashi, E; Hussain-Yusuf, H; Onodera, R; Bungo, T; Sato, H; Furuse, M;
Indirizzi:
Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Adv Anim & MarineBioresources, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 neBioresources, Fukuoka 8128581, Japan Miyazaki Univ, Fac Agr, Lab Anim Nutr & Biochem, Miyazaki 8892192, Japan Miyazaki Univ Miyazaki Japan 8892192 & Biochem, Miyazaki 8892192, Japan Ehime Univ, Fac Agr, Dept Agrobiol Sci, Lab Anim Sci, Matsuyama, Ehime 7908566, Japan Ehime Univ Matsuyama Ehime Japan 7908566 Matsuyama, Ehime 7908566, Japan Ajinomoto Co Inc, Kawasaki, Kanagawa 2108681, Japan Ajinomoto Co Inc Kawasaki Kanagawa Japan 2108681 Kanagawa 2108681, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 310, anno: 2001,
pagine: 97 - 100
SICI:
0304-3940(20010914)310:2-3<97:IIOPAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PHYSIOLOGICAL FLUIDS; HEPATO-RENAL SYNDROME; PLASMA-LEVELS; LYSINE; METABOLISM; MECHANISM; BRAIN;
Keywords:
L-pipecolic acid; GABAergic system; intracerebroventricular administration; sleeping-like behavior; neonatal chicks;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Furuse, M Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Lab Adv Anim & MarineBioresources, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 rces, Fukuoka 8128581, Japan
Citazione:
T. Takagi et al., "Intracerebroventricular injection of pipecolic acid inhibits food intake and induces sleeping-like behaviors in the neonatal chick", NEUROSCI L, 310(2-3), 2001, pp. 97-100

Abstract

It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate Of L-Lysine (L-Lys) in the brain, is involved in the functioning of Gamma -aminobutyric acid. In the present work the effect of intracerebroventricular (i.c.v.) administration of L-PA, and its relatives, on food intake and behavior in neonatal chicks was investigated. The i.c.v. injection of 1 Mg of L-PA and D-PA significantly inhibited food intake during the 2h following injection, whereas greater than 2 Mg of L-Lys was required to inhibit food intake, In behavioral tests, the i.c.v. injection of L-PA reduced active wakefulness and feeding behavior while inducing sleeping-like behavior in chicks. These results suggest that L-PA has an important role forthe regulation of behaviors in the neonatal chick after conversion from L-Lys in the brain. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:31:05