Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of zenarestat, an aldose reductase inhibitor, on endoneurial blood flow in experimental diabetic neuropathy of rat
Autore:
Kihara, M; Mitsui, Y; Shioyama, M; Hasegawa, T; Takahashi, M; Takakura, S; Minoura, K; Kawamura, I;
Indirizzi:
Kinki Univ, Sch Med, Dept Neurol, Osaka 589, Japan Kinki Univ Osaka Japan 589 Univ, Sch Med, Dept Neurol, Osaka 589, Japan Fujisawa Pharmaceut Co Ltd, Med Biol Res Labs, Osaka 532, Japan Fujisawa Pharmaceut Co Ltd Osaka Japan 532 ol Res Labs, Osaka 532, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 2-3, volume: 310, anno: 2001,
pagine: 81 - 84
SICI:
0304-3940(20010914)310:2-3<81:EOZAAR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE-CONDUCTION-VELOCITY; SCIATIC-NERVE; NITRIC-OXIDE; VASOREACTIVITY; COMPLICATIONS; TOLRESTAT;
Keywords:
aldose reductase inhibitor; nerve blood flow; nitric oxide; diabetic neuropathy; zenarestat; hydrogen clearance; microelectrode;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Kihara, M Kinki Univ, Sch Med, Dept Neurol, Osaka 589, Japan Kinki Univ Osaka Japan 589 Med, Dept Neurol, Osaka 589, Japan
Citazione:
M. Kihara et al., "Effect of zenarestat, an aldose reductase inhibitor, on endoneurial blood flow in experimental diabetic neuropathy of rat", NEUROSCI L, 310(2-3), 2001, pp. 81-84

Abstract

The effects of zenarestat, an aldose reductase inhibitor, on endoneurial blood flow (NBF) were explored in streptozotocin-induced diabetic rats. Ratswere maintained on a diet of containing 0.09% zenarestat for 8 weeks, thenNBF in the sciatic nerve was measured using microelectrode hydrogen polarography. NBF in the diabetic control rats was significantly lower than values in age-matched control rats, however, NBF was not significantly altered in diabetic rats treated with zenarestat. Direct application of nitric oxidesynthase inhibitor, NG-nitro-L-arginine, did not affect NBF in diabetic control rats, whereas this application significantly reduced NBF both in age-matched control and zenarestat treated diabetic rats. Considerable levels of zenarestat were confirmed in the sciatic nerve in the drug treated rats. These data suggest that aldose reductase, such as zenarestat, might restoreor prevent the alteration of endoneurial blood flow resulting from an impairment of nitric oxide function. (C) 2001 Elsevier Science Ireland Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:30:52