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Titolo:
Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
Autore:
Novitch, BG; Chen, AI; Jessell, TM;
Indirizzi:
Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ New York NY USA 10032obiol & Behav, New York, NY 10032 USA
Titolo Testata:
NEURON
fascicolo: 5, volume: 31, anno: 2001,
pagine: 773 - 789
SICI:
0896-6273(20010913)31:5<773:CROMNS>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGENITOR-CELL IDENTITY; CENTRAL-NERVOUS-SYSTEM; VENTRAL SPINAL-CORD; PRONEURAL GENES; HOMEOBOX GENES; COMMISSURAL INTERNEURONS; TRANSCRIPTION FACTORS; HOMEODOMAIN PROTEIN; MAMMALIAN-CELLS; DEVELOPING CNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Jessell, TM Columbia Univ, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, Ctr Neurobiol & Behav, 701 W 168th St, New York, NY 10032 USA ColumbiaUniv 701 W 168th St New York NY USA 10032 Y 10032 USA
Citazione:
B.G. Novitch et al., "Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2", NEURON, 31(5), 2001, pp. 773-789

Abstract

Within the developing vertebrate nervous system, the mechanisms that coordinate neuronal subtype identity with generic features of neuronal differentiation are poorly defined. We show here that a bHLH protein, Olig2, is expressed selectively by motor neuron progenitors and has a key role in specifying the subtype identity and pan-neuronal properties of developing motor neurons. The role of Olig2 in the specification of motor neuron subtype identity depends on regulatory interactions with progenitor homeodomain proteins, whereas its role in promoting pan-neuronal properties is associated with expression of another bHLH protein, Ngn2. Both aspects of Olig2 function appear to depend an its activity as a transcriptional repressor. Together, these studies show that Olig2 has a critical role in integrating diverse features of motor neuron differentiation in the developing spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:15:55