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Titolo:
TNF alpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS
Autore:
Killestein, J; Kalkers, NF; Meilof, JF; Barkhof, F; van Lier, RAW; Polman, CH;
Indirizzi:
Vrije Univ Amsterdam, Med Ctr, Dept Neurol, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Vrije Univ Amsterdam, Med Ctr, MS MRI Ctr, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1007 MB erdam, Netherlands Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Dept Immunobiol, Amsterdam, Netherlands Netherlands Red Cross Amsterdam Netherlands iol, Amsterdam, Netherlands
Titolo Testata:
NEUROLOGY
fascicolo: 6, volume: 57, anno: 2001,
pagine: 1129 - 1131
SICI:
0028-3878(20010925)57:6<1129:TAPBCT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; MULTIPLE-SCLEROSIS; DISEASE-ACTIVITY; EXPRESSION; GAMMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Polman, CH Vrije Univ Amsterdam, Med Ctr, Dept Neurol, POB 7057, NL-1007 MB Amsterdam, Netherlands Vrije Univ Amsterdam POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
J. Killestein et al., "TNF alpha production by CD4(+) T cells predicts long-term increase in lesion load on MRI in MS", NEUROLOGY, 57(6), 2001, pp. 1129-1131

Abstract

Reliable laboratory prognostic factors for MS are still lacking. The predictive value of markers of T-cell activation for long-term disease progression was investigated. Flow cytometry measurements were correlated to changesin Expanded Disability Status Scale and MR T2 lesion load over 36 months in 14 patients with secondary progressive MS, A correlation was found between the percentage of tumor necrosis factor-a-producing CD4(+) T cells at baseline and the change in T2 lesion load during 3-year follow-up (r = 0.79, adjusted r(2) = 0.59, p = 0.001).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:21:04