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Titolo:
Neural correlates of attention and working memory deficits in HIV patients
Autore:
Chang, L; Speck, O; Miller, EN; Braun, J; Jovicich, J; Koch, C; Itti, L; Ernst, T;
Indirizzi:
Univ Calif Los Angeles, Harbor UCLA Med Ctr, Sch Med, Dept Neurol, Torrance, CA 90509 USA Univ Calif Los Angeles Torrance CA USA 90509 urol, Torrance, CA 90509 USA Univ Calif Los Angeles, Harbor UCLA Med Ctr, Sch Med, Dept Psychiat, Torrance, CA 90509 USA Univ Calif Los Angeles Torrance CA USA 90509 hiat, Torrance, CA 90509 USA Univ Calif Los Angeles, Harbor UCLA Med Ctr, Sch Med, Dept Radiol, Torrance, CA 90509 USA Univ Calif Los Angeles Torrance CA USA 90509 diol, Torrance, CA 90509 USA CALTECH, Computat & Neural Syst Program, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125 Neural Syst Program, Pasadena, CA 91125 USA
Titolo Testata:
NEUROLOGY
fascicolo: 6, volume: 57, anno: 2001,
pagine: 1001 - 1007
SICI:
0028-3878(20010925)57:6<1001:NCOAAW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL MAGNETIC-RESONANCE; COGNITIVE MOTOR COMPLEX; MULTICENTER AIDS COHORT; HUMAN PREFRONTAL CORTEX; BRAIN ACTIVATION; METABOLITE ABNORMALITIES; DEMENTIA COMPLEX; HOMOSEXUAL MEN; INDIVIDUALS; TASK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, L Brookhaven Natl Lab, Dept Med, Bldg 490, Upton, NY 11973 USA Brookhaven Natl Lab Bldg 490 Upton NY USA 11973 ton, NY 11973 USA
Citazione:
L. Chang et al., "Neural correlates of attention and working memory deficits in HIV patients", NEUROLOGY, 57(6), 2001, pp. 1001-1007

Abstract

Objectives: To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1. Method: fMRI was used to evaluate brain activity in 11 patients with HIV and 11 age-, sex-, education-, and handedness-matched seronegative subjects, while performing a battery of tasks that required different levels of attention for working memory. Results: Patients with HIV showed greater brain activation (blood oxygenation level dependent signal changes) in some regions compared with control subjects while performing the same tasks. For the simpler tasks, patients with HIV showed greater activation in the parietal regions. However, with more difficult tasks, patients with HIV showed greater activation additionally in the frontal lobes. Reaction times during these tasks were slower but accuracy was similar in the patients with HIV compared with control subjects. Conclusion: Injury to the neural substrate caused by HIV infection may necessitate greater attentional modulation of the neural circuits, hence a greater use of the brain reserve; additional activation of the frontal lobes is required to perform the more complex tasks. The task-dependent increased frontal activation in patients with HIV suggests that the neural correlate of attentionaldeficits may be excessive attentional modulation as a result of frontostriatal brain injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:04:06