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Titolo:
Mizoribine ameliorates the tubulointerstitial fibrosis of obstructive nephropathy
Autore:
Sato, N; Shiraiwa, K; Kai, K; Watanabe, A; Ogawa, S; Kobayashi, Y; Yamagishi-Imai, H; Utsunomiya, Y; Mitarai, T;
Indirizzi:
Asahi Chem Ind Co Ltd, Life Sci Res Inst, Toxicol Res Lab, Ohito, Shizuoka4102321, Japan Asahi Chem Ind Co Ltd Ohito Shizuoka Japan 4102321 Shizuoka4102321, Japan Jikei Univ, Sch Med, Dept Internal Med 2, Tokyo, Japan Jikei Univ Tokyo Japan Univ, Sch Med, Dept Internal Med 2, Tokyo, Japan Saitama Med Sch, Med Ctr, Dept Internal Med 4, Moroyama, Saitama, Japan Saitama Med Sch Moroyama Saitama Japan l Med 4, Moroyama, Saitama, Japan
Titolo Testata:
NEPHRON
fascicolo: 2, volume: 89, anno: 2001,
pagine: 177 - 185
SICI:
0028-2766(200110)89:2<177:MATTFO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL URETERAL OBSTRUCTION; RENAL-ALLOGRAFT RECIPIENTS; INTERSTITIAL FIBROSIS; MYCOPHENOLATE-MOFETIL; EXPERIMENTAL HYDRONEPHROSIS; CYCLOSPORINE; MACROPHAGES; EXPRESSION; INFILTRATION; MECHANISMS;
Keywords:
unilateral ureteral obstruction; tubulointerstitial fibrosis; macrophages; T lymphocytes; osteopontin; mizoribine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Sato, N Asahi Chem Ind Co Ltd, Life Sci Res Inst, Toxicol Res Lab, 632-1 Mifuku, Ohito, Shizuoka 4102321, Japan Asahi Chem Ind Co Ltd 632-1 Mifuku Ohito Shizuoka Japan 4102321 an
Citazione:
N. Sato et al., "Mizoribine ameliorates the tubulointerstitial fibrosis of obstructive nephropathy", NEPHRON, 89(2), 2001, pp. 177-185

Abstract

Mizoribine has been shown to possess an immunosuppressive action that inhibits the proliferation of lymphocytes selectively by interfering with inosine monophosphate dehydrogenase. Recent studies have demonstrated that mizoribine improves renal tubulointerstitial fibrosis in the rat model of unilateral ureteral obstruction (UUO) by inhibiting the infiltration of macrophages. We, therefore, examined the dose dependency of the suppressive effect of mizoribine on the infiltration of interstitial macrophages and T lymphocytes and the interstitial volume in UUO-treated kidneys. Furthermore, we investigated the expression of osteopontin (OPN), known to be a chemoattractant protein for macrophages, in the renal cortex. In rats with UUO, the interstitial volume was markedly expanded, and macrophage and T lymphocyte infiltration in the interstitium and the expression of OPN in the cortical tubules were greatly increased. Treatment with mizoribine ameliorated the increase in interstitial volume induced by UUO. Interstitial infiltration of macrophages and T lymphocytes was dose dependently suppressed by mizoribine, and the decreased macrophage infiltration was correlated with inhibition of tubular OPN expression. These results suggest that mizoribine has a beneficial effect on several steps contributing to the progression of tubulointerstitial fibrosis caused by obstruction of the ureter. Copyright (C) 2001 S. Karger AG, Base.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:34:21