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Titolo:
Genetic susceptibility and environmental estrogen-like compounds
Autore:
Kristensen, VN; Kure, EH; Erikstein, B; Harada, N; Borresen-Dale, AL;
Indirizzi:
Norwegian Radium Hosp, Inst Canc Res, Dept Genet, N-0310 Oslo, Norway Norwegian Radium Hosp Oslo Norway N-0310 Dept Genet, N-0310 Oslo, Norway Tellemark Cent Hosp, Dept Occupat & Environm Med, N-3710 Skien, Norway Tellemark Cent Hosp Skien Norway N-3710 vironm Med, N-3710 Skien, Norway Norwegian Radium Hosp, Inst Canc Res, Dept Oncol, N-0310 Oslo, Norway Norwegian Radium Hosp Oslo Norway N-0310 Dept Oncol, N-0310 Oslo, Norway Fujita Hlth Univ, Sch Med, Dept Biochem, Toyoake, Aichi 47011, Japan Fujita Hlth Univ Toyoake Aichi Japan 47011 m, Toyoake, Aichi 47011, Japan
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 482, anno: 2001,
pagine: 77 - 82
SICI:
1386-1964(20011001)482:1-2<77:GSAEEC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER-CELLS; EXPRESSION; RISK; POLYMORPHISM; INHIBITION; CHEMICALS; SULFATASE; P450C21; HEALTH; CYP17;
Keywords:
17-beta-hydroxysteroid dehydrogenase; estrogen metabolism; polymorphism; breast cancer risk;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Kristensen, VN Norwegian Radium Hosp, Inst Canc Res, Dept Genet, N-0310 Oslo, Norway Norwegian Radium Hosp Oslo Norway N-0310 310 Oslo, Norway
Citazione:
V.N. Kristensen et al., "Genetic susceptibility and environmental estrogen-like compounds", MUT RES-F M, 482(1-2), 2001, pp. 77-82

Abstract

Environmental chemicals with estrogenic activities have been suggested to be able to interact with the endocrine system. Endogenous estrogen is synthesized in the ovarian theca cells of premenopausal women or in the stromal adipose cells of the breast of postmenopausal women and minor quantities inperipheral tissue. These cells, as well as breast tissue, express all the necessary enzymes for this synthesis, CYP17, CYP11a, CYP19, 17-beta -hydroxysteroid hydrogenase, steroid sulfatase as well as enzymes further hydroxylating estradiol, such as CYP1A1, CYP3A4, CYP1B1, catechol-o-methyltransferase (COMT). Polymorphisms in these enzymes may have a possible role in the link between environmental estrogens and hormone-like substances and the interindividual risk of breast cancer. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 18:03:36