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Titolo:
Glutathione S-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans
Autore:
Dusinska, M; Ficek, A; Horska, A; Raslova, K; Petrovska, H; Vallova, B; Drlickova, M; Wood, SG; Stupakova, A; Gasparovic, J; Bobek, P; Nagyova, A; Kovacikova, Z; Blazicek, P; Liegebel, U; Collins, AR;
Indirizzi:
Inst Prevent & Clin Med, Dept Mol & Genet Toxicol, Bratislava 83301, Slovakia Inst Prevent & Clin Med Bratislava Slovakia 83301 islava 83301, Slovakia Rowett Res Inst, Aberdeen AB21 9SB, Scotland Rowett Res Inst Aberdeen Scotland AB21 9SB , Aberdeen AB21 9SB, Scotland Hosp Minist Def, Bratislava, Slovakia Hosp Minist Def Bratislava Slovakia sp Minist Def, Bratislava, Slovakia Univ Jena, D-6900 Jena, Germany Univ Jena Jena Germany D-6900Univ Jena, D-6900 Jena, Germany
Titolo Testata:
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
fascicolo: 1-2, volume: 482, anno: 2001,
pagine: 47 - 55
SICI:
1386-1964(20011001)482:1-2<47:GSPITL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPRESSION; PLASMA; ACID; 8-HYDROXYDEOXYGUANOSINE; SUSCEPTIBILITY; CLONING; BLADDER; CANCER; ASSAY; CDNA;
Keywords:
glutathione S-transferase polymorphisms oxidative DNA damaged; antioxidant enzymes; smoking; vitamin C; biomarkers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Dusinska, M Inst Prevent & Clin Med, Dept Mol & Genet Toxicol, Limbova 14,Bratislava 83301, Slovakia Inst Prevent & Clin Med Limbova 14 Bratislava Slovakia 83301
Citazione:
M. Dusinska et al., "Glutathione S-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans", MUT RES-F M, 482(1-2), 2001, pp. 47-55

Abstract

Glutathione S-transferase genotypes GSTT1. GSTM1, GSTP1 were characterisedin 155 middle-aged men and compared with parameters of oxidative stress atthe level of DNA and lipids, with antioxidant enzymes, and with plasma antioxidants in smokers and non-smokers. Smokers had on average significantly lower levels of Vitamin C, beta -carotene and beta -cryptoxanthin and higher amounts of oxidised purities and pyrimidines in lymphocyte DNA. The GSTM1null genotype was associated with elevated glutathione as well as with higher Vitamin C concentration in plasma. Vitamin C was higher in GSTT1+ compared with GSTT1 null - as was glucose-6-phosphate dehydrogenase activity. The homozygous GSTP1 a/a genotype was associated with significantly higher levels of GST activity measured in lymphocytes, in comparison with the b/b genotype. Using multifactorial statistical analysis we found significant associations between smoking, GSTP1 genotype, plasma Vitamin C, and purine basedamage in lymphocyte DNA. The difference in Vitamin C plasma levels between smokers and non-smokers was seen only with the GSTP1 b/b genotype. This group accounted also for most of the increase in purine oxidation in smokers. In contrast, the link between smoking and oxidised pyrimidines in DNA wasseen only in the GSTT1 null group. It seems that polymorphisms in the phase II metabolising enzyme glutathione S-transferase may be important determinants of commonly measured biomarkers. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:50:43