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Titolo:
Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats
Autore:
Oshiro, Y; Shimabukuro, M; Takasu, N; Asahi, T; Komiya, I; Yoshida, H;
Indirizzi:
Univ Ryukyus, Fac Med, Dept Internal Med 2, Okinawa 9030215, Japan Univ Ryukyus Okinawa Japan 9030215 nternal Med 2, Okinawa 9030215, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 16, volume: 69, anno: 2001,
pagine: 1907 - 1918
SICI:
0024-3205(20010907)69:16<1907:TCICOA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE; CORONARY-ARTERY; VENTRICULAR DYSFUNCTION; ISCHEMIC-INJURY; NA+/H+ EXCHANGE; SHORT-TERM; HEARTS; REPERFUSION; CARDIOMYOPATHY; PERFORMANCE;
Keywords:
thyroid hormone; ischemia-reperfusion; heart; diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Shimabukuro, M Univ Ryukyus, Fac Med, Dept Internal Med 2, 207 Uehara, Okinawa 9030215, Japan Univ Ryukyus 207 Uehara Okinawa Japan 9030215 30215, Japan
Citazione:
Y. Oshiro et al., "Triiodothyronine concomitantly inhibits calcium overload and postischemic myocardial stunning in diabetic rats", LIFE SCI, 69(16), 2001, pp. 1907-1918

Abstract

Acute effects of triiodothyronine (T-3) on postischemic myocardial stunning and intracellular Ca2+ contents were studied in the isolated working hearts of streptozotocin-induced diabetic rats and age-matched controls. After two weeks of diabetes, serum T-3 and T-4 levels were decreased to 62.5% and33.9% of control values. Basal preischemic cardiac performance did not differ between diabetic and control rats. In contrast, during reperfusion after 20-min ischemia, diabetic rats exhibited an impaired recovery of heart rate (at 30-min reperfusion 57.5% of baseline vs. control 88.5%), left ventricular (LV) systolic pressure (44.1% vs. 89.5%), and cardiac work (23.1% vs.66.0%). When 1 and 100 nM T-3 was added before ischemia, heart rate was recovered to 77.2% and 81.8% of baseline, LV systolic pressure to 68.3% and 81.9%, and cardiac work to 50.8% and 59.0%, respectively. Diabetic rat hearts showed a higher Ca2+ content in the basal state and a further increase after reperfusion (4.96 +/-1.17 vs. control 3.78 +/-0.48 mu mol/g, p<0.01). In diabetic hearts, H+ release was decreased after reperfusion (5.24<plus/minus>2.21 vs. 8.70 +/-1.41 mmol/min/g, p<0.05). T-3 administration caused a decrease in the postischemic Call accumulation (1nM T-3 4.66<plus/minus>0.41 and 100 nM T-3 3.58 +/-0.36) and recovered the H+ release (1nM T-3 16.2 +/-3.9 and 100 nM T-3 11.6 +/-0.9). T-3 did not alter myocardial O-2 Consumption. Results suggest that diabetic rat hearts are vulnerable to postischemic stunning, and T-3 protects the myocardial stunning possibly via inhibiting Ca2+ overload. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:17:44