Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Serum cystatin C-immunoglobulin high-molecular-weight complexes in kidney and liver transplant patients
Autore:
Hermida, J; Romero, R; Tutor, JC;
Indirizzi:
Hosp Clin Univ, Cent Lab, Santiago De Compostela, Spain Hosp Clin Univ Santiago De Compostela Spain ntiago De Compostela, Spain Hosp Clin Univ, Serv Nefrol, Santiago De Compostela, Spain Hosp Clin UnivSantiago De Compostela Spain ntiago De Compostela, Spain
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 4, volume: 60, anno: 2001,
pagine: 1561 - 1564
SICI:
0085-2538(200110)60:4<1561:SCCHCI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; ASPARTATE-AMINOTRANSFERASE; SENSITIVE MARKER; RENAL-FUNCTION; CREATININE; GFR; MACROENZYME; CLEARANCE; CHILDREN; ADULTS;
Keywords:
glomerular filtration rate; polyethylene glycol 6000; marker for GFR; creatinine; end-stage renal disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Tutor, JC Hosp Clin Univ, Cent Lab, Santiago De Compostela, Spain Hosp Clin Univ Santiago De Compostela Spain Compostela, Spain
Citazione:
J. Hermida et al., "Serum cystatin C-immunoglobulin high-molecular-weight complexes in kidney and liver transplant patients", KIDNEY INT, 60(4), 2001, pp. 1561-1564

Abstract

Background. It has been suggested recently that the glomerular filtration rate (GFR) in renal transplant patients is underestimated by serum cystatinC clue to all impaired filtration of complexed cystatin C with immunoglobulins. Consequently, serum cystatin C may not be a reliable marker of GFR inthese patients. Our study was designed to determine whether this supposition is correct. Methods. In 87 serum samples from patients with various kidney diseases. 182 samples from renal transplant patients, and 72 samples from liver transplant patients, the concentrations of cystatin C and creatinine were determined, as well as the residual concentration of cystatin C after precipitation of macromolecules with polyethylene glycol (PEG; 6000 molecular weight). Results. The residual concentration of serum cystatin C after precipitation with PEG in all cases was much higher (70 to 100%) than that expected in the case of the existence of cystatin C-immunoglobulin complexes. In the kidney and liver transplant patients, there was no significant correlation between the residual concentration of cystatin C and the postoperative time (r = -0.098). Conclusions. The results suggest that in renal or liver transplant patients there is no formation of high molecular weight serum cystatin C-immunoglobulin complexes, regardless of the post-transplant period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:26:38