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Titolo:
Nrf2-deficient female mice develop lupus-like autoimmune nephritis
Autore:
Yoh, K; Itoh, K; Enomoto, A; Hirayama, A; Yamaguchi, N; Kobayashi, M; Morito, N; Koyama, A; Yamamoto, M; Takahashi, S;
Indirizzi:
Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Clin Med, Tsukuba, Ibaraki 3058575, Japan Univ TsukubaTsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Ctr TARA, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Mito Saiseikai Gen Hosp, Dept Internal Med, Mito, Ibaraki, Japan Mito Saiseikai Gen Hosp Mito Ibaraki Japan nal Med, Mito, Ibaraki, Japan Tokyo Med Coll, Kasumigaura Hosp, Dept Nephrol, Ibaraki, Osaka, Japan Tokyo Med Coll Ibaraki Osaka Japan , Dept Nephrol, Ibaraki, Osaka, Japan
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 4, volume: 60, anno: 2001,
pagine: 1343 - 1353
SICI:
0085-2538(200110)60:4<1343:NFMDLA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROPHILE-RESPONSIVE ELEMENT; BZIP TRANSCRIPTION FACTOR; PLANAR AROMATIC-COMPOUNDS; ANTI-DNA ANTIBODIES; YA-SUBUNIT GENE; INDUCIBLE EXPRESSION; LIPID-PEROXIDATION; ERYTHEMATOSUS SLE; OXIDATIVE STRESS; HEME OXYGENASE-1;
Keywords:
oxidative stress; transcriptional activator; antioxidant enzymes; cell injury; autoimmune disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, S Univ Tsukuba, Inst Basic Med Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki Japan 3058575 pan
Citazione:
K. Yoh et al., "Nrf2-deficient female mice develop lupus-like autoimmune nephritis", KIDNEY INT, 60(4), 2001, pp. 1343-1353

Abstract

Background. NF-E2-related factor 2 (Nrf2) is a basic leucine zipper transcriptional activator essential for the coordinate transcriptional induction of antioxidant enzymes and phase Il drug metabolizing enzymes through the antioxidant response element/electrophile response element. The Nrf2-deficient mice were found to develop normally under standard laboratory conditions, However, upon closer examination, we found that aged female Nrf2-deficient mice displayed a shortened lifespan and developed severe glomerulonephritis. The present study investigated the glomerulonephritis findings in Nrf2-deficient mice. Methods. To evaluate glomerular lesions of Nrf2-deficient mice, histological and functional analyses were performed. The amounts of serum immunoglobulins. anti-double-stranded (cls) DNA antibody, and lipid peroxidation usingthiobarbituric acid reactive substances (TBARS) also were measured. Results. Nrf2-deficient female mice over 60 weeks of age developed severe nephritis characterized by cellular proliferation, lobular formation, crescent formation, and subepithelial electron-dense deposits. In immunofluorescent assays, Nrf2-deficient female mice showed mesangial deposits and massive granular deposits of IgG, IgM, and C3 along the capillary walls. Higher serum levels of IgG, anti-dsDNA antibody, lower creatinine clearance, and slight splenomegaly also were found in Nrf2-deficient female mice. A higher concentration of TBARS also was found in Nrf2-deficient female mice. Conclusions. These data indicate that the aged Nrf2-deficient female mice develop lupus-like autoimmune nephritis and suggest that nrf2 is one of thegenes determining susceptibility to autoimmune disease. Analysis of nephritis in the Nrf2-deficient female mouse may clarify the mechanisms leading to the development of lupus disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 14:01:53