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Titolo:
Virological response to interferon therapy of chronic hepatitis B as measured by a highly sensitive assay
Autore:
Lindh, M; Hannoun, C; Horal, P; Krogsgaard, K;
Indirizzi:
Gothenburg Univ, Dept Clin Virol, S-41346 Gothenburg, Sweden Gothenburg Univ Gothenburg Sweden S-41346 ol, S-41346 Gothenburg, Sweden Hvidovre Univ Hosp, Clin Res Unit, Copenhagen, Denmark Hvidovre Univ HospCopenhagen Denmark lin Res Unit, Copenhagen, Denmark
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 5, volume: 8, anno: 2001,
pagine: 349 - 357
SICI:
1352-0504(200109)8:5<349:VRTITO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; TERM FOLLOW-UP; HUMAN LYMPHOBLASTOID INTERFERON; CONTROLLED TRIAL; ALPHA-INTERFERON; VIRUS-DNA; E-ANTIGEN; PREDNISONE WITHDRAWAL; CORE PROMOTER; VIRAL REPLICATION;
Keywords:
hepatitis B virus; quantification; response; steroid; therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Lindh, M Gothenburg Univ, Dept Clin Virol, Guldhedsgatan 10B, S-41346 Gothenburg, Sweden Gothenburg Univ Guldhedsgatan 10B Gothenburg Sweden S-41346eden
Citazione:
M. Lindh et al., "Virological response to interferon therapy of chronic hepatitis B as measured by a highly sensitive assay", J VIRAL HEP, 8(5), 2001, pp. 349-357

Abstract

In the interferon (IFN) treatment of chronic hepatitis B, there is no accepted definition of virological response as measured by highly sensitive HBVDNA assays. In the present study of 98 patients given IFN (10 MU/day for 1week, then 10 MU TIW for 11 weeks) with or without prednisolone priming, avirological response was identified as log HBV DNA/mL below 6.0 (by Amplicor Monitor, Roche) 6 months post-treatment. At this time, 92% (33/36) of the sustained responders (SR) still had detectable viraemia with log HBV DNA/mL at 4.30 +/- 0.15 ( SEM), as compared with 8.69 +/- 0.097 in nonsustainedresponders. Pretreatment viraemia below a threshold at 500 million copies/mL was associated with higher chance of response (P = 0.023). Prednisolone enhanced the sustained response (53% vs. 30%, P = 0.025), and in particularend-of-treatment response (ETR, 50% vs. 10%, P < 0.0001). ETR was predictive for SR (P < 0.0001), especially when log HBV DNA/mL was < 4.0 (PPV = 92%). The potential value of differentiating the therapy of chronic hepatitis B on the basis of viraemia levels, as measured by highly sensitive assays, should be further investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 11:01:59