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Titolo:
Hematologic abnormalities and outcome of 16 cats with myelodysplastic syndromes
Autore:
Hisasue, M; Okayama, H; Okayama, T; Suzuki, T; Mizuno, T; Fujino, Y; Naganobu, K; Hasegawa, A; Watari, T; Matsuki, N; Masuda, K; Ohno, K; Tsujimoto, H;
Indirizzi:
Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 rnal Med, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Clin Pathobiol, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 athobiol, Bunkyo Ku, Tokyo 1138657, Japan Miyazaki Univ, Fac Agr, Dept Vet Pharmacol, Miyazaki 88921, Japan MiyazakiUniv Miyazaki Japan 88921 Vet Pharmacol, Miyazaki 88921, Japan Nihon Univ, Sch Vet Med, Dept Pathobiol, Kanagawa, Japan Nihon Univ Kanagawa Japan Sch Vet Med, Dept Pathobiol, Kanagawa, Japan Nihon Univ, Sch Vet Med, Lab Comprehens Vet Clin Studies, Kanagawa, Japan Nihon Univ Kanagawa Japan Comprehens Vet Clin Studies, Kanagawa, Japan
Titolo Testata:
JOURNAL OF VETERINARY INTERNAL MEDICINE
fascicolo: 5, volume: 15, anno: 2001,
pagine: 471 - 477
SICI:
0891-6640(200109/10)15:5<471:HAAOO1>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
FELINE LEUKEMIA-VIRUS; LONG TERMINAL REPEATS; MYELOPROLIFERATIVE DISORDERS; MYELOID-LEUKEMIA; APLASTIC-ANEMIA; CELL APLASIA; CLASSIFICATION; RETROVIRUS; PATHOGENESIS;
Keywords:
feline leukemia virus; French-American British classification; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Tsujimoto, H Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1138657, Japan Univ Tokyo 1-1-1 Yayoi Tokyo Japan 1138657 yo 1138657, Japan
Citazione:
M. Hisasue et al., "Hematologic abnormalities and outcome of 16 cats with myelodysplastic syndromes", J VET INT M, 15(5), 2001, pp. 471-477

Abstract

We investigated the hematologic abnormalities and prognoses in 16 cats with myelodysplastic syndromes (MDS). Nonregenerative anemia, thrombocytopenia, and neutropenia were observed in 15, 13, and 4, respectively, of the 16 cats with MDS. Morphologic abnormalities characteristic of MDS included megaloblastoid rubricytes (9 cats), hyposegmentation of neutrophils (7 cats). nuclear abnormality of rubricytes (10 cats) and neutrophils (13 cats), and micromegakaryocytes (10 cats). Disease in these 16 cats was subclassified into refractory anemia (RA; 8 cats), RA with excess of blasts (RAEB; 5 cats),RAEB in transformation (RAEB in T, 1 cat), and chronic myelomonocytic leukemia (CMMoL 2 cats), according to the human French-American-British (FAB) classification. In the cats in which the clinical outcome was known. 3 of 6 cats with high blast cell count MDS, including RAEB, RAEB in T and CMMoL. developed acute myeloid leukemia, but only I of 8 cats with low blast cell count MDS (RA) developed acute myeloid leukemia. Based on the Dusseldorf scoring system for the prognosis of human MDS, the survival times of the cats showing high scores (greater than or equal to3 points) were significantly shorter than those of the cats with low scores (<3 points). The FAB classification and Dusseldorf scoring system were considered to be useful for predicting the prognosis of feline MDS. Furthermore, 15 of the 16 cats with MDS in this study were infected with feline leukemia virus, indicating its possible etiologic role in the pathogenesis of feline MDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:52:54