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Titolo:
Expression of transforming growth factor-alpha in adenoid cystic carcinomaof the salivary gland
Autore:
Chiang, CP; Chen, CH; Liu, BY; Sun, A; Leu, JS; Wang, JT;
Indirizzi:
Natl Taiwan Univ, Coll Med, Sch Dent, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 Med, Sch Dent, Taipei 10018, Taiwan China Med Coll Hosp, Dept Dent, Taichung, Taiwan China Med Coll Hosp Taichung Taiwan l Hosp, Dept Dent, Taichung, Taiwan China Med Coll, Sch Dent, Taichung, Taiwan China Med Coll Taichung Taiwan ina Med Coll, Sch Dent, Taichung, Taiwan
Titolo Testata:
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
fascicolo: 7, volume: 100, anno: 2001,
pagine: 471 - 477
SICI:
0929-6646(200107)100:7<471:EOTGFI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMAS; TGF-ALPHA; FACTOR RECEPTOR; PREMALIGNANT LESIONS; HUMAN KERATINOCYTES; PROTEIN; CANCER; HEAD; LOCALIZATION; TISSUES;
Keywords:
transforming growth factor-alpha; adenoid cystic carcinoma; salivary gland; labial minor; submandibular gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Chiang, CP Natl Taiwan Univ Hosp, Sch Dent, 1 Chang Te St, Taipei, Taiwan Natl Taiwan Univ Hosp 1 Chang Te St Taipei Taiwan pei, Taiwan
Citazione:
C.P. Chiang et al., "Expression of transforming growth factor-alpha in adenoid cystic carcinomaof the salivary gland", J FORMOS ME, 100(7), 2001, pp. 471-477

Abstract

Background: Transforming growth factor-alpha (TGF-alpha) is expressed in both normal and malignant epithelial cells. Although the expression of TGF-alpha has been extensively studied in some human epithelia] neoplasms, its expression in adenoid cystic carcinomas (ACCs) of the salivary gland has notbeen reported. Methods. This study used an immunohistochemical technique to assess the expression of TGF-alpha in 40 ACC specimens from the salivary glands, seven specimens front labial minor salivary glands adjacent to mucoceles, and fivespecimens from normal submandibular glands. Results: In the normal submandibular gland specimens, positive TGF-alpha staining was found in all ductal segments as well as in serous and some mucous acinar cells. In labial minor salivary glands adjacent to mucoceles, positive TGF-alpha staining was found in ductal, serous acinar, serous demilune, and a few mucous acinar cells. Positive TGF-alpha immunostaining was observed in all five salivary gland ACC specimens with a solid histologic pattern, and 31 of the 35 salivary gland ACC specimens with a tubulo-cribriformhistologic pattern. Overall, 36 of 40 ACCs of the salivary gland expressedTGF-alpha. Positive TGF-alpha staining was found in the salivary gland ACCspecimens with solid, tubular, duct-like, and pseudocystic structures. No significant correlation was found between TGF-alpha expression in ACCs of the salivary gland and age, sex, primary cancer location, TNM status, clinical stage, prognosis, histologic type, perivascular or perineural invasion, focal necrosis of the tumor, or cellular atypia. Conclusions: This study demonstrated that ductal and acinar cells of the normal submandibular gland and of labial minor salivary glands adjacent to mucoceles are the major sites of TGF-alpha synthesis and secretion. Furthermore, TGF-alpha is biosynthesized in salivary gland ACC tumor cells, formingsolid, tubular, duct-like, and pseudocystic structures. Our data suggest that TGF-alpha may play an important biologic role as a mitogen in the growth of salivary gland ACC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 12:31:34