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Titolo:
Remodeling of resistance arteries in renal failure: Effect of endothelin receptor blockade
Autore:
Amann, K; Miltenberger-Miltenyi, G; Simonoviciene, A; Koch, A; Orth, S; Ritz, E;
Indirizzi:
Univ Erlangen Nurnberg, Dept Pathol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univ Heidelberg, Dept Pathol, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany Univ Heidelberg, Dept Internal Med, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ed, D-6900 Heidelberg, Germany Univ Bern, Inselspital, Div Nephrol & Hypertens, CH-3010 Bern, SwitzerlandUniv Bern Bern Switzerland CH-3010 Hypertens, CH-3010 Bern, Switzerland
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 10, volume: 12, anno: 2001,
pagine: 2040 - 2050
SICI:
1046-6673(200110)12:10<2040:RORAIR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; BLOOD-PRESSURE; UREMIC RATS; DISEASE; ANTAGONISTS; MORPHOLOGY; PREVENTS; MISMATCH; HEART; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Amann, K Univ Erlangen Nurnberg, Dept Pathol, Krankenhausstr 8-10, D-91054Erlangen, Germany Univ Erlangen Nurnberg Krankenhausstr 8-10 Erlangen Germany D-91054
Citazione:
K. Amann et al., "Remodeling of resistance arteries in renal failure: Effect of endothelin receptor blockade", J AM S NEPH, 12(10), 2001, pp. 2040-2050

Abstract

Remodeling of vessels is a known feature of renal failure, but it is unclear whether this represents an appropriate or inappropriate response to the known changes in blood flow, shear stress. and wall tension. To investigateremodeling in response to variations in blood flow, first-order mesentericarteries were exposed to high- and low-flow conditions via the ligation ofsecond-order branches, according to the technique described by Pourageaud and De Mey. The resulting changes in vessel geometric features, relative proportions of intima and media, submicroscopic structure, and immunostainingfor proliferating cell nuclear antigen (PCNA), endothelin-1 (ET-1), and ETA receptors were assessed in first-order mesenteric arteries under low-flowand high-flow conditions. Subtotally nephrectomized (SNX) animals were compared with sham-operated rats. Animals either were left untreated or were treated with the ETA receptor antagonist (ET-RA) LU-135252, because of suggestions in the literature that ET is involved in vascular remodeling in uremia. A highly significant increase in intimal thickness was noted in low-flow arteries (4.21 +/-1.39 mum) of SNX animals, compared with normal-flow arteries (2.06 +/-0.61 mum), but this increase was not observed in sham-operated rats (1.38 +/-0.77 in low-flow arteries versus 2.40 +/-0.35 mum in normal-flow arteries). The increase in intimal thickness in low-flow arteries was abrogated by ET-RA_ ne medial thickness was increased in untreated SNX animals (19.5 +/-3.61 mum), compared with sham-operated rats, and this increase was also prevented by ET-RA. The medial thickness was not affected by low flow in either sham-operated or SNX animals. In parallel, the number of PCNA-positive intimal cells was higher in low-flow, but not high-flow, arteries of SNX rats, compared with sham-operated rats. No significant change was observed in sham-operated animals. In the media, the number of PCNA-positive cells was higher in untreated SNX animals than in sham-operated rats. The number was even more markedly increased in high-flow, but not low-flow, vessels. This increase was abrogated by ET-RA. It is concluded that, in uremic animals, the response of the intima to low flow and the response of themedia to high flow are exaggerated. Both responses are apparently mediatedby ET.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:48:01