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Titolo:
Quantification of the spectrum of changes in regional myocardial function during acute ischemia in closed chest pigs: An ultrasonic strain rate and strain study
Autore:
Jamal, F; Kukulsi, T; Strotmann, J; Szilard, M; Dhooge, J; Bijnens, B; Rademakers, F; Hatle, L; De Scheerder, I; Sutherland, GR;
Indirizzi:
Univ Hosp Gasthuisberg, Dept Cardiol, B-3000 Louvain, Belgium Univ Hosp Gasthuisberg Louvain Belgium B-3000 l, B-3000 Louvain, Belgium Univ Hosp Wurzburg, Dept Cardiol, Wurzburg, Germany Univ Hosp Wurzburg Wurzburg Germany rg, Dept Cardiol, Wurzburg, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
fascicolo: 9, volume: 14, anno: 2001,
pagine: 874 - 884
SICI:
0894-7317(200109)14:9<874:QOTSOC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE DOPPLER-ECHOCARDIOGRAPHY; CORONARY-ARTERY DISEASE; DOBUTAMINE STRESS; WALL-MOTION; BLOOD-FLOW; LEFT-VENTRICLE; CONTRACTION; DYSFUNCTION; RELAXATION; OCCLUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Sutherland, GR Univ Hosp Gasthuisberg, Dept Cardiol, Herestr 49, B-3000 Louvain, Belgium Univ Hosp Gasthuisberg Herestr 49 Louvain Belgium B-3000 m
Citazione:
F. Jamal et al., "Quantification of the spectrum of changes in regional myocardial function during acute ischemia in closed chest pigs: An ultrasonic strain rate and strain study", J AM S ECHO, 14(9), 2001, pp. 874-884

Abstract

The objectives of this study were to define the spectrum of regional myocardial function changes during acute ischemia. in closed chest animals by using newly developed ultrasonic strain rate and strain Indexes derived from regional color Doppler myocardial imaging (CDMI) velocity data. Myocardial ischemia was induced in 18 pigs either with acute total 20-second occlusions (group 1, n = 12) or graded hypoperfusion (40 to 0 mL/min, group 2, n = 6) of the circumflex coronary artery. in addition, a dobutamine challenge (5to 10 mug/kg per minute) was performed during sustained subtotal ischemia (10 mL/min) in group 2. CDMI acquisitions with parasternal views monitored the myocardial posterior wall function. Regional radial strain rate and strain (epsilon (r)) were measured for systole, isovolumic relaxation, early diastole, and atrial filling, respectively. During total and graded ischemia, epsilon (r) profiles were consistently modified, showing a delayed onset and a decrease in regional systolic thickening as well as increased postsystolic thickening. Radial strain rate and epsilon (r) indexes decreased consistently during systole and early diastole and increased during isovolumic relaxation. End-systolic epsilon (r), could differentiate total ischemia from severe hypoperfusion (10 mL/min), decreasing from 32% +/- 8% to 16% +/- 5% (versus 60% +/- 10% at baseline). During dobutamine infusion (10 mug/kg per minute), end-systolic epsilon (r) tended to decrease from 27% +/- 5% to18% +/- 11%, whereas postsystolic thickening increased by 2-fold (P < .05). The combined analysis of regional deformation characteristics and global cardiac event timing derived from CDMI data can identify and quantify regional function changes induced by experimental acute ischemia in closed chestpigs. This would appear to be a potentially promising new noninvasive approach to the clinical evaluation of ischemia-induced changes in segmental myocardial function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:53:32