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Titolo:
A four-dimensional probabilistic atlas of the human brain
Autore:
Mazziotta, J; Toga, A; Evans, A; Fox, P; Lancaster, J; Zilles, K; Woods, R; Paus, T; Simpson, G; Pike, B; Holmes, C; Collins, L; Thompson, P; MacDonald, D; Iacoboni, M; Schormann, T; Amunts, K; Palomero-Gallagher, N; Geyer, S; Parsons, L; Narr, K; Kabani, N; Le Goualher, G; Feidler, J; Smith, K; Boomsma, D; Pol, HH; Cannon, T; Kawashima, R; Mazoyer, B;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA , Sch Med, Los Angeles, CA USA McGill Univ, Montreal, PQ, Canada McGill Univ Montreal PQ CanadaMcGill Univ, Montreal, PQ, Canada Univ Texas, San Antonio, TX 78285 USA Univ Texas San Antonio TX USA 78285Univ Texas, San Antonio, TX 78285 USA Univ Dusseldorf, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 rf, D-4000 Dusseldorf, Germany Univ Calif San Francisco, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Res Ctr Julich, Inst Med, Julich, Germany Res Ctr Julich Julich GermanyRes Ctr Julich, Inst Med, Julich, Germany Mitre Corp, Mclean, VA USA Mitre Corp Mclean VA USAMitre Corp, Mclean, VA USA Vrije Univ Amsterdam, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands rdam, Amsterdam, Netherlands Univ Utrecht, Med Ctr, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands Utrecht, Med Ctr, Utrecht, Netherlands Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA Univ CalifLos Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Tohoku Univ, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 ohoku Univ, Sendai, Miyagi 980, Japan Univ Caen, F-14032 Caen, France Univ Caen Caen France F-14032Univ Caen, F-14032 Caen, France
Titolo Testata:
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
fascicolo: 5, volume: 8, anno: 2001,
pagine: 401 - 430
SICI:
1067-5027(200109/10)8:5<401:AFPAOT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CEREBRAL-CORTEX; POSITRON-EMISSION-TOMOGRAPHY; E EPSILON-4 ALLELE; MAGNETIC-RESONANCE IMAGES; APOLIPOPROTEIN-E GENOTYPE; CORPUS-CALLOSUM SIZE; HUMAN VISUAL-CORTEX; ALZHEIMERS-DISEASE; IN-VIVO; INTERSUBJECT VARIABILITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
182
Recensione:
Indirizzi per estratti:
Indirizzo: Mazziotta, J Ahmanson Lovelace Brain Mapping Ctr, 660 Charles E Young Dr S, Los Angeles, CA 90095 USA Ahmanson Lovelace Brain Mapping Ctr 660 CharlesE Young Dr S Los Angeles CA USA 90095
Citazione:
J. Mazziotta et al., "A four-dimensional probabilistic atlas of the human brain", J AM MED IN, 8(5), 2001, pp. 401-430

Abstract

The authors describe the development of a four-dimensional atlas and reference system that includes both macroscopic and microscopic information on structure and function of the human brain in persons between the ages of 18 and 90 years. Given the presumed large but previously unquantified degree of structural and functional variance among normal persons in the human population, the basis for this atlas and reference system is probabilistic. Through the efforts of the International Consortium for Brain Mapping (ICBM), 7,000 subjects will be included in the initial phase of database and atlas development. For each subject, detailed demographic, clinical, behavioral, and imaging information is being collected. In addition, 5,800 subjects will contribute DNA for the purpose of determining genotype-phenotype-behavioral correlations. The process of developing the strategies, algorithms, datacollection methods, validation approaches, database structures, and distribution of results is described in this report. Examples of applications of the approach are described for the normal brain in both adults and childrenas well as in patients with schizophrenia. This project should provide newinsights into the relationship between microscopic and macroscopic structure and function in the human brain and should have important implications in basic neuroscience, clinical diagnostics, and cerebral disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:32:41