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Titolo:
Excretion and transmission of JCV in human populations
Autore:
Bofill-Mas, S; Girones, R;
Indirizzi:
Univ Barcelona, Dept Microbiol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 crobiol, E-08028 Barcelona, Spain
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 4, volume: 7, anno: 2001,
pagine: 345 - 349
SICI:
1355-0284(200108)7:4<345:EATOJI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS-DNA; PCR AMPLIFICATION; POLLUTED WATERS; SIMIAN-VIRUS-40; ADENOVIRUS; SHELLFISH; SEQUENCES; MUCOSA;
Keywords:
excretion; JC virus DNA; polluted food; polluted waters; polymerase chain reaction; sequence analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Girones, R Univ Barcelona, Dept Microbiol, Abg Diagona 645, E-08028 Barcelona, Spain Univ Barcelona Abg Diagona 645 Barcelona Spain E-08028 , Spain
Citazione:
S. Bofill-Mas e R. Girones, "Excretion and transmission of JCV in human populations", J NEUROVIRO, 7(4), 2001, pp. 345-349

Abstract

The potential transmission of JCV through the environment has been analyzed by studying the JC viruses present in raw sewage of urban populations from widely divergent geographical areas. High numbers of JCV were found. JCV was detected in 98% (51/52) of sewage samples from different geographical areas in Europe, Africa, and USA by applying a Nested-PCR procedure. The mean estimated concentration of JCV in sewage was of 10(2)-10(3) viral particles/ml. Sequence analysis shows that JCV found in environmental samples present an archetypal structure in the regulatory region as it has been described in urine samples. Cerebrospinal fluid samples (CSF) of PML (progressive multifocal leucoencephalopathy) patients were also analyzed as control samples in this study presenting tandem repeats and rearrangements at the regulatory region (RR). Sequence analysis of the intergenic region (IGR) allowedthe typification and phylogenetic analysis of the JCV sequences detected in sewage. JC viral particles were also found to be stable in sewage samplesat 20 degreesC for more than 70 days. This data suggest the idea that the intake of water or food contaminated with JCV could constitute a portal of entry for the virus or the viral DNA to the human organism.

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Documento generato il 07/07/20 alle ore 22:10:43